Parkin protects against mitochondrial toxins and beta-amyloid accumulation in skeletal muscle cells

The Journal of Biological Chemistry
Kenneth M RosenHenry W Querfurth

Abstract

Mutations in the ubiquitin ligase-encoding Parkin gene have been implicated in the pathogenesis of autosomal recessive Parkinson disease. Outside of the central nervous system, Parkin is prominently expressed in skeletal muscle. We have found accumulations of Parkin protein in skeletal muscle biopsies taken from patients with inclusion body myositis, a degenerative disorder in which intramyofiber accumulations of the beta-amyloid peptide are pathognomonic. In comparing primary cultures of skeletal muscle derived from parkin knock-out and wild-type mice, we have found the absence of parkin to result in greater sensitivity to mitochondrial stressors rotenone and carbonyl cyanide 3-chlorophenylhydrazone, without any alteration in sensitivity to calcium ionophore or hydrogen peroxide. Utilizing viral expression constructs coding for the Alzheimer disease and inclusion body myositis-linked beta-amyloid precursor protein and for its metabolic byproducts A beta42 and C100, we found that parkin knock-out muscle cells are also more sensitive to the toxic effects of intracellular A beta. We also constructed a lentiviral system to overexpress wild-type Parkin and have shown that boosting the levels of parkin expression in normal skeletal ...Continue Reading

References

Feb 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·V AskanasW K Engel
Mar 27, 1996·Biochemical and Biophysical Research Communications·E M JohnstoneS P Little
Nov 1, 1996·Journal of Neuropathology and Experimental Neurology·S Carpenter
Nov 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y ZhangT M Dawson
Nov 20, 2001·Current Opinion in Pharmacology·M C Dalakas
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael C SugarmanFrank M LaFerla
May 10, 2002·The American Journal of Pathology·Michael G SchlossmacherKenneth S Kosik
Sep 28, 2002·Current Opinion in Neurology·Valerie Askanas, W King Engel
Oct 11, 2002·Human Molecular Genetics·Andrew B WestMatt J Farrer
Feb 18, 2003·Human Molecular Genetics·Frédéric DariosAlexis Brice
Mar 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jessica C GreeneLeo J Pallanck
Aug 22, 2003·The Journal of Biological Chemistry·Matthew S GoldbergJie Shen
Sep 16, 2003·The Journal of Biological Chemistry·Konstanze F WinklhoferJörg Tatzelt
Dec 26, 2003·The American Journal of Pathology·Gaetano VattemiValerie Askanas
Feb 20, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jordi MagranéHenry W Querfurth
Feb 27, 2004·The Journal of Biological Chemistry·James J PalacinoJie Shen
Oct 27, 2004·Cell and Tissue Research·Rainer von CoellnTed M Dawson

❮ Previous
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Citations

Feb 12, 2009·Apoptosis : an International Journal on Programmed Cell Death·Vladimir GogvadzeBoris Zhivotovsky
Dec 8, 2009·Journal of Bioenergetics and Biomembranes·Alexander J Whitworth, Leo J Pallanck
Jun 19, 2008·Journal of Molecular Neuroscience : MN·Charbel E-H Moussa
Apr 21, 2012·The Journal of Biological Chemistry·Simona BoncompagniAlexander Shtifman
Jul 22, 2008·Human Molecular Genetics·Jose A Rodríguez-NavarroMaria A Mena
Jun 2, 2009·Human Molecular Genetics·Mark P BurnsCharbel E-H Moussa
Jul 21, 2009·Human Molecular Genetics·Oliver RothfussNadja Patenge
Oct 24, 2008·Current Opinion in Rheumatology·Michael J Garlepp, Frank L Mastaglia
Jul 23, 2009·BMJ : British Medical Journal·Steven A Greenberg
Aug 7, 2010·PloS One·Mareike E FettKonstanze F Winklhofer
Mar 13, 2012·International Journal of Environmental Research and Public Health·Syed F AliSyed Z Imam
Aug 20, 2014·BioMed Research International·Soraya ScuderiVelia D'Agata
Aug 19, 2011·Antioxidants & Redox Signaling·Alzbeta TrancikovaDarren J Moore
Nov 20, 2009·The International Journal of Neuroscience·Hasmet A HanagasiMurat Emre
Jan 23, 2016·Frontiers in Aging Neuroscience·Cheng-Wu ZhangKah-Leong Lim
May 7, 2013·Progress in Neurobiology·Sudhakar Raja Subramaniam, Marie-Francoise Chesselet
Jul 18, 2009·Journal of Neuroscience Research·Kenneth M RosenHenry W Querfurth
Aug 30, 2011·Biochimica Et Biophysica Acta·Pinar CoskunDouglas C Wallace
Jun 11, 2008·Neuroscience Letters·Furong Yu, Jianhua Zhou
May 15, 2007·Current Opinion in Neurobiology·Mark W Dodson, Ming Guo
May 8, 2007·Neuroscience Letters·Wakako TamoKei Satoh
Jul 12, 2007·Journal of Neurochemistry·Jose A Rodríguez-NavarroMaria A Mena
May 17, 2012·Neurobiology of Disease·Han-Kyu LeeHenry Querfurth
Sep 8, 2009·Biochimica Et Biophysica Acta·Konstanze F Winklhofer, Christian Haass
Apr 20, 2016·Free Radical Biology & Medicine·Raquel Requejo-Aguilar, Juan P Bolaños
Feb 24, 2015·Molecular and Cellular Neurosciences·Rakshita A Charan, Matthew J LaVoie
Sep 28, 2013·Neuroscience·M Sonia AngelineP Kumar
Dec 3, 2013·Biochimica Et Biophysica Acta·Aaron P RussellGlenn D Wadley
Dec 9, 2008·Biochimica Et Biophysica Acta·Rebecca BanerjeeBobby Thomas
Dec 4, 2010·Journal of Pharmacological Sciences·Syoko TanakaJunko Kimura
Jun 13, 2012·Free Radical Biology & Medicine·Micha M M WilhelmusJack van Horssen
Mar 22, 2018·American Journal of Physiology. Cell Physiology·Nesibe PekerRavi Kambadur
Mar 24, 2017·Brain : a Journal of Neurology·Jenny SassoneAndrea Ciammola
May 31, 2018·American Journal of Physiology. Endocrinology and Metabolism·Chris Chin Wah ChenDavid A Hood
Dec 7, 2013·Journal of Virology·Shivanjali Joshi-BarrChristina J Sigurdson
Aug 14, 2019·Scientific Reports·Lyudmila KovalchukeLloyd A Greene
Mar 20, 2019·Neurochemical Research·Wilasinee SuwanjangKomgrid Charngkaew

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