Parkinsonian motor features distinguish the agrammatic from logopenic variant of primary progressive aphasia.

Parkinsonism & Related Disorders
Jonathan Graff-RadfordKeith A Josephs

Abstract

Few studies have assessed parkinsonian motor features across variants of primary progressive aphasia (PPA). Our objective was to compare degree of parkinsonian motor features between two PPA variants. Parkinsonian motor features were assessed with the unified Parkinson's disease rating scale in prospectively recruited PPA subjects, classified based on recently published criteria. Comparisons across groups were performed with Fisher's exact test for binary data and Mann-Whitney U test for continuous data. Twenty-three PPA subjects were diagnosed with logopenic (n = 11) or nonfluent/agrammatic (n = 12) aphasia. There were no significant differences in illness duration (agrammatic = 3.4 years; logopenic = 3.3 years) or age at onset (nonfluent/agrammatic = 67.3; logopenic = 62.0), but those with logopenic aphasia were more impaired on mini-mental state examination (21.7/30 points vs. 26.1/30; p = 0.04). In contrast, those with logopenic aphasia had fewer parkinsonian motor features than those with agrammatic aphasia (5.7/132 vs. 16.8/132; p = 0.003) which was driven by bradykinesia (p = 0.02) and speech facial/expression (p = 0.04); less so rigidity (p = 0.06). Dysarthria was more frequent in the nonfluent/agrammatic subgroup. Nonf...Continue Reading

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Citations

May 29, 2014·Journal of Movement Disorders·Hee Kyung Park, Sun J Chung
Nov 23, 2013·Parkinsonism & Related Disorders·Jonathan Graff-RadfordNeill R Graff-Radford
Jul 21, 2015·Neurologia i neurochirurgia polska·Emilia J SitekJarosław Sławek
May 18, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S Gil-NavarroR Sánchez-Valle
Dec 3, 2014·Revue neurologique·E MagninJ-F Démonet
Oct 14, 2014·Aphasiology·Joseph R DuffyKeith A Josephs
Feb 3, 2018·Journal of Neurology·Charles R MarshallJason D Warren
Mar 16, 2017·Journal of Speech, Language, and Hearing Research : JSLHR·Matthew L PooleAdam P Vogel
Sep 10, 2020·Applied Neuropsychology. Adult·Maria Rita Lo MonacoMaria Caterina Silveri
Mar 6, 2018·Journal of Alzheimer's Disease : JAD·John R Hodges, Olivier Piguet
Dec 12, 2017·Brain : a Journal of Neurology·Katerina A TetzloffJennifer L Whitwell
Oct 5, 2021·Journal of Neuroinflammation·Aitana Sogorb-EsteveJonathan D Rohrer

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