Parkinsonism Relating to Intoxication with Glyphosate

Internal Medicine
Makoto EriguchiHideo Hara

Abstract

We herein report the case of a 38-year-old man who developed parkinsonism 4 years after ingesting glyphosate. The patient presented with right-sided bradykinesia and cogwheel rigidity without autonomic symptoms. Magnetic resonance imaging of the brain and [123I]-metaiodobenzylguanidine myocardial scintigraphy were normal. A drastic response to levodopa and the presence of levodopa-induced dyskinesia without strong non-motor symptoms were seen in this patient. We considered that young-onset atypical parkinsonism was associated with a history of sublethal glyphosate ingestion. Epidemiologic investigations have shown that exposure to pesticides is a risk factor for Parkinson's disease (PD). Our findings support the notion that glyphosate exposure might be related to the onset of PD.

References

Jun 8, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·E R BarbosaC C Leite
Nov 16, 2002·Archives of Neurology·Helen PetrovitchLon R White
Aug 7, 2003·Neuroepidemiology·Isabelle BaldiPatrick Brochard
Nov 4, 2008·Nature Clinical Practice. Neurology·Claire Henchcliffe, M Flint Beal
Jan 17, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H SawadaT Kawamura
Jul 31, 2009·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Ying-Ju ChenChen-Chang Yang
Jan 29, 2011·Environmental Health Perspectives·Caroline M TannerJ William Langston
Mar 4, 2011·Parkinsonism & Related Disorders·Gang WangSheng-Di Chen
Apr 17, 2012·Neurotoxicology and Teratology·Ya-xing GuiSheng-di Chen
Mar 29, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Areski ChorfaThierry Baron
Oct 17, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Ronald B PostumaGünther Deuschl
Oct 19, 2016·Lancet Neurology·Alberto Ascherio, Michael A Schwarzschild
Jun 1, 2017·The Laryngoscope·Gaurav S AjmaniJayant M Pinto
Feb 6, 2018·Parkinsonism & Related Disorders·Qian ZhengZhu Xu

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Citations

Sep 9, 2020·Journal of Immunotoxicology·Cindy Peillex, Martin Pelletier
Apr 30, 2020·International Journal of Environmental Research and Public Health·Feng ZhangBaoli Zhu
Jan 7, 2022·Annual Review of Pharmacology and Toxicology·Xiaojing WangMaría-Aránzazu Martínez

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