Parkinson's disease: an autoimmune process

The International Journal of Neuroscience
R A Barker, A P Cahn

Abstract

Parkinson's disease (PD) is a common condition that, in the majority of cases, is idiopathic in origin. The loss of central dopaminergic pathways is well-known and in this paper a theory is presented that this is brought about by an autoimmune process. The lack of any HLA association or familial clumping for the disease does not exclude such a theory, as a common etiological agent may exist that we do not yet recognize, e.g., infection, or drugs. Several autoantibodies and disturbances in T-cell function have been found in PD. The theory proposes that the production of autoantibodies and T-cell activation are important in the pathogenesis of idiopathic PD by an action on the substance P striatonigral pathway and its input to the dopaminergic nigrostriatal pathway. The autoimmune destruction of the substance P input leads to a secondary loss of the dopaminergic system and hence PD.

References

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Citations

Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·R VolpiV Coiro
Oct 12, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jessica A Hutter SaundersHoward E Gendelman
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Nov 5, 2016·Cell Research·Rosalind F Roberts, Edward A Fon
Feb 17, 2017·Parkinsonism & Related Disorders·Arun Parashar, Malairaman Udayabanu
Apr 3, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Bart P C van de WarrenburgNiall P Quinn
Feb 24, 2019·Reviews in the Neurosciences·Ava NasrolahiJavad Mahmoudi
Apr 1, 1993·Reviews in the Neurosciences·R Barker, S Dunnett

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