Parkinson's disease and bacteriophages as its overlooked contributors

Scientific Reports
George V TetzVictor Tetz

Abstract

Recent studies suggest that alterations in the gut phagobiota may contribute to pathophysiological processes in mammals; however, the association of bacteriophage community structure with Parkinson's disease (PD) has not been yet characterized. Towards this end, we used a published dataset to analyse bacteriophage composition and determine the phage/bacteria ratio in faecal samples from drug-naive PD patients and healthy participants. Our analyses revealed significant alterations in the representation of certain bacteriophages in the phagobiota of PD patients. We identified shifts of the phage/bacteria ratio in lactic acid bacteria known to produce dopamine and regulate intestinal permeability, which are major factors implicated in PD pathogenesis. Furthermore, we observed the depletion of Lactococcus spp. in the PD group, which was most likely due to the increase of lytic c2-like and 936-like lactococcal phages frequently present in dairy products. Our findings add bacteriophages to the list of possible factors associated with the development of PD, suggesting that gut phagobiota composition may serve as a diagnostic tool as well as a target for therapeutic intervention, which should be confirmed in further studies. Our result...Continue Reading

References

Jun 1, 1991·Lancet·Y Agid
Jan 1, 1991·Intervirology·A W JarvisM Teuber
Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·L L EdwardsM Balluff
Jul 10, 2003·Lancet Neurology·Ronald F Pfeiffer
Jun 7, 2005·Trends in Microbiology·Mya Breitbart, Forest Rohwer
Jun 28, 2005·Current Opinion in Microbiology·Marie-Christine ChopinElena Bidnenko
Feb 6, 2009·Molecular Neurodegeneration·Mark R Cookson
Jun 23, 2009·Applied and Environmental Microbiology·Geneviève M Rousseau, Sylvain Moineau
Aug 17, 2010·Bioinformatics·Robert C Edgar
Jan 5, 2011·Nature Reviews. Microbiology·Marilyn J Roossinck
Apr 28, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuhua WangWenke Feng
Jun 13, 2012·Nature Methods·Nicola SegataCurtis Huttenhower
Aug 7, 2012·Nature Reviews. Microbiology·Alejandro ReyesJeffrey I Gordon
Sep 13, 2012·Nature Reviews. Neuroscience·John F Cryan, Timothy G Dinan
Sep 29, 2012·Neurobiology of Disease·David DevosPascal Derkinderen
Oct 16, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yasunari AsanoNobuyuki Sudo
Dec 14, 2012·Gut·Ana Elena Pérez-CobasAndrés Moya
Jan 1, 2013·Bacteriophage·Mariángeles Briggiler MarcóAndrea Quiberoni
Feb 8, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·C Warren Olanow, Patrik Brundin
Jun 19, 2013·Journal of Dairy Science·James MurphyDouwe van Sinderen
Mar 14, 2014·The ISME Journal·Alison S WallerPeer Bork
Mar 25, 2014·Trends in Microbiology·Marion DalmassoR Paul Ross
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Eric A FranzosaCurtis Huttenhower
Jul 6, 2014·Advances in Experimental Medicine and Biology·Rebecca WallCatherine Stanton
Aug 8, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas ClairembaultPascal Derkinderen
Dec 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Filip ScheperjansPetri Auvinen
Dec 30, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Joaquin A VizcarraAlberto J Espay
Apr 24, 2015·Lancet·Lorraine V Kalia, Anthony E Lang
May 29, 2015·Journal of Virology·Graham F Hatfull
Jul 8, 2015·Environmental Health Perspectives·Beate RitzOle Raaschou-Nielsen
Sep 30, 2015·Nature Methods·Duy Tin TruongNicola Segata
Oct 13, 2015·World Journal of Gastroenterology : WJG·Agata Mulak, Bruno Bonaz
Oct 28, 2015·Nature Reviews. Neurology·Lisa Klingelhoefer, Heinz Reichmann
Feb 20, 2016·Scientific Reports·James MurphyDouwe van Sinderen
Nov 5, 2016·Parkinsonism & Related Disorders·Marcus M UngerKarl-Herbert Schäfer
Nov 3, 2016·Current Opinion in Neurology·Filip Scheperjans

❮ Previous
Next ❯

Citations

Nov 15, 2018·International Journal of Molecular Sciences·Małgorzata Kujawska, Jadwiga Jodynis-Liebert
May 2, 2019·Journal of Neurology·Michal LubomskiCarolyn M Sue
Oct 15, 2019·Journal of Parkinson's Disease·T Van LaarA Horta Herranz
Feb 28, 2020·Microbial Cell Factories·Liang Shen
May 23, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Claudia VuottoGiovanna Borsellino
Jul 31, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Huimin ZhengYuming Xu
Dec 24, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Michela BarichellaGianni Pezzoli
Jun 20, 2019·Frontiers in Neurology·Susanne Fonseca SantosAntonio Pereira
Oct 5, 2019·Mediators of Inflammation·Anshul Sinha, Corinne F Maurice
Feb 13, 2020·Scientific Reports·George TetzVictor Tetz
Jun 26, 2020·Scientifica·Ramendra Dirgantara Putra, Diana Lyrawati
Oct 6, 2020·Frontiers in Cellular and Infection Microbiology·Emma Guerin, Colin Hill
Oct 30, 2019·BMC Biology·Sanzhima GarmaevaAlexandra Zhernakova
Jan 11, 2020·Frontiers in Neurology·Aeja JacksonAli Keshavarzian
Aug 28, 2019·International Journal of Molecular Sciences·Parisa Gazerani
Oct 1, 2020·Medical Microbiology and Immunology·Xue-Rui YinXiao-Qun Zheng
Jan 22, 2021·Archives of Microbiology·Sabrina RoyerDeivid William da Fonseca Batistão
Feb 14, 2020·Cell Host & Microbe·Mohammadali Khan MirzaeiCorinne F Maurice
Mar 2, 2021·Frontiers in Aging Neuroscience·Ting ShenHsin-Yi Lai
Nov 19, 2018·Parkinsonism & Related Disorders·Guillaume ChapeletPascal Derkinderen
Apr 28, 2021·Ageing Research Reviews·Shen-Yuan ZhengHan-Deng Liu
Oct 17, 2020·Neural Regeneration Research·Vanessa CastelliAnnamaria Cimini
May 13, 2021·Journal of the American Chemical Society·Magdalena Jancheva, Thomas Böttcher
May 20, 2021·Cell Reports·Sanzhima GarmaevaAlexandra Zhernakova
Jul 3, 2021·Microorganisms·George Tetz, Victor Tetz
Aug 28, 2021·International Journal of Molecular Sciences·Magdalena PodlachaAlicja Węgrzyn
Oct 1, 2021·Communications Biology·Stephen R StockdaleColin Hill
Jan 19, 2022·Movement Disorders : Official Journal of the Movement Disorder Society·Morgane LinardCatherine Helmer
Mar 3, 2021·Cellular and Molecular Neurobiology·Nitu DograDeepshikha Pande Katare

❮ Previous
Next ❯

Software Mentioned

MetaPhlAn
Metaphalan
BLAST
phyloseq R library
MetaPhlAn2
R
metaSPAdes
PERMANOVA
Bowtie2

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

Related Papers

Zentralblatt Für Bakteriologie, Parasitenkunde, Infektionskrankheiten Und Hygiene. Zweite Naturwissenschaftliche Abt.: Allgemeine, Landwirtschaftliche Und Technische Mikrobiologie
H RAETTIG
© 2022 Meta ULC. All rights reserved