Parkinson's disease and risk of hip fracture: systematic review and meta-analysis

Acta neurologica Belgica
Ali HosseinzadehAli Akbar Haghdoost

Abstract

The relationship between Parkinson's disease (PD) and risk of hip fracture yielded inconsistent results. Therefore, we conducted the present systematic review and meta-analysis of published observational studies to assess the association between PD and risk of hip fracture. PubMed, ISI, EMBASE, and Cochrane databases were searched systematically to identify studies assessing the relationship between PD and the risk of hip fracture up to July 01, 2017. In addition, to find related articles, the reference section of retrieved articles was checked. Random-effects model was used for calculation of pooled hazard ratio (HR) and 95% confidence intervals (CI). Thirteen independent studies containing 564,947 participants were included in the meta-analysis. The overall results of included studies showed PD to be associated with the risk of hip fracture (HRoverall = 3.13, 95% CI 2.53-3.87) in women 3.11 (2.51-3.86) and men 2.60 (2.19-3.09). Our meta-analysis showed the direct association between PD and the risk of hip fracture in both men and women. However, due to the limitations of this study, further well-designed studies are required to confirm our findings.

References

Jul 1, 1979·Clinical Science·R WoottonM Tellez-Yudilevich
Aug 1, 1976·Age and Ageing·I R BrownP H Millard
May 9, 1991·The New England Journal of Medicine·J A GrissoF Kaplan
Jun 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C Snow-HarterR Marcus
Jun 1, 1989·Clinical Rheumatology·P Minaire
Sep 1, 1986·Age and Ageing·O Johnell, I Sernbo
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Jul 1, 1981·Journal of Gerontology·G Wyshak
Mar 23, 1995·The New England Journal of Medicine·S R CummingsT M Vogt
Nov 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·O JohnellG Lyritis
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L J Melton
Jan 4, 2001·Journal of the Neurological Sciences·Y SatoK Oizumi
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
Jan 24, 2003·The American Journal of Clinical Nutrition·Diane FeskanichGraham A Colditz
Sep 3, 2004·Journal of the American Geriatrics Society·Brent C TaylorKristine E Ensrud
Feb 25, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Akihiro YamanashiAkira Nagano
May 20, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Marco Y C PangAndrew S Dawson
Aug 23, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Yoshihiro SatoKei Satoh
Sep 3, 2005·Journal of the American Geriatrics Society·Howard A FinkUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Group
Dec 27, 2005·Joint, Bone, Spine : Revue Du Rhumatisme·Nathalie Vaserman
Mar 18, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·D R WilliamsA J Lees
May 17, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·L Joseph MeltonWalter A Rocca
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Aug 21, 2007·Calcified Tissue International·Peter VestergaardLeif Mosekilde
Sep 11, 2007·Acta Neurologica Scandinavica·B LorefältA-K Granérus
Feb 28, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J L SchneiderUNKNOWN Study of Osteoporotic Fractures (SOF) Research Group
Apr 1, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D D Bikle
Oct 15, 2008·Archives of Neurology·Marian L EvattVin Tangpricha
Dec 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jane A CauleyUNKNOWN Study of Osteoporotic Fractures Research and Group
Apr 3, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A SantosJ Klein-Nulend
Jun 3, 2009·American Journal of Physical Medicine & Rehabilitation·Roberto Cano-de-la-CuerdaCesar Fernández-de-Las-Peñas
Jun 16, 2009·Lancet·Andrew J LeesTamas Revesz
Jan 15, 2010·Methods in Molecular Biology·Leslie Rosenthal, Enrique Schisterman
Jan 12, 2011·Indian Journal of Orthopaedics·Dinesh K DhanwalCyrus Cooper
Feb 3, 2012·Parkinsonism & Related Disorders·Yen-Yu ChenChien-Hsu Lai
Nov 8, 2012·Age and Ageing·Frederiek van den BosHarald J J Verhaar
Dec 5, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J T SchousboeK E Ensrud
Feb 8, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Richard W WalkerWilliam K Gray
Feb 23, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S PouwelsF de Vries
Mar 22, 2013·Journal of Orthopaedic Trauma·Amanda L JohnsonAnthony G Sanzone

❮ Previous
Next ❯

Citations

Apr 11, 2020·Journal of Osteoporosis·Maryna BystrytskaNina Karasevich

❮ Previous
Next ❯

Software Mentioned

STATA
MOOSE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.