Parkinson's disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions.

BMC Biology
Federico BaldiniNCER-PD Consortium

Abstract

Parkinson's disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their functional consequences remain unclear. Herein, we addressed this question by an analysis of stool samples from the Luxembourg Parkinson's Study (n = 147 typical PD cases, n = 162 controls). All individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed by self-reporting questionnaires. Stool samples from these individuals were first analysed by 16S rRNA gene sequencing. Second, we predicted the potential secretion for 129 microbial metabolites through personalised metabolic modelling using the microbiome data and genome-scale metabolic reconstructions of human gut microbes. Our key results include the following. Eight genera and seven species changed significantly in their relative abundances between PD patients and healthy controls. PD-associated microbial patterns statistically depended on sex, age, BMI, and constipation. Particularly, the relative abundances of Bilophila and Paraprevotella were significantly associated with the Hoehn and Yahr staging aft...Continue Reading

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Citations

Oct 10, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ethan G Brown, Samuel M Goldman
Feb 2, 2021·Surgical Infections·Abdurakhmon T BabakhanovTimur M Saliev
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Aug 6, 2021·Current Opinion in Pharmacology·Priyanka BaloniNathan D Price
Jul 28, 2021·Annual Review of Microbiology·Almut HeinkenInes Thiele

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Methods Mentioned

BETA
PCR
Illumina sequencing

Software Mentioned

panSpeciesModel
Merging and Filtering tool ( MeFit )
ADONIS
AGORA
STATA
MATLAB
R vegan
R ( R Foundation for Statistical Computing
Anosim
SPINGO

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