Parkinson's disease: Exit toxins, enter genetics.

Progress in Neurobiology
Marie WesterlundLars Olson

Abstract

Parkinson's disease was long considered a non-hereditary disorder. Despite extensive research trying to find environmental risk factors for the disease, genetic variants now stand out as the major causative factor. Since a number of genes have been implicated in the pathogenesis it seems likely that several molecular pathways and downstream effectors can affect the trophic support and/or the survival of dopamine neurons, subsequently leading to Parkinson's disease. The present review describes how toxin-based animal models have been valuable tools in trying to find the underlying mechanisms of disease, and how identification of disease-linked genes in humans has led to the development of new transgenic rodent models. The review also describes the current status of the most common genetic susceptibility factors for Parkinson's disease identified up to today.

References

Jan 1, 1975·Biochemical Pharmacology·C Sachs, G Jonsson
Feb 23, 1987·Life Sciences·W J NicklasR E Heikkila
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Dec 1, 1968·European Journal of Pharmacology·U Ungerstedt
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K UédaT Saitoh
Nov 15, 1996·Science·M H PolymeropoulosR C Duvoisin
Feb 13, 1997·Biochemical and Biophysical Research Communications·D NagakuboH Ariga
Aug 28, 1997·Nature·M G SpillantiniM Goedert
Oct 17, 1998·Nature·E LeroyM H Polymeropoulos
Feb 3, 1999·JAMA : the Journal of the American Medical Association·C M TannerJ W Langston
Dec 2, 2000·Nature Neuroscience·R BetarbetJ T Greenamyre
Dec 15, 2000·The New England Journal of Medicine·S SveinbjörnsdottirK Stefansson
Jul 4, 2001·Nature Reviews. Neuroscience·M Goedert
Jul 20, 2001·American Journal of Human Genetics·C M van DuijnP Heutink
Jan 29, 2002·Free Radical Research·A Mitsumoto, Y Nakagawa
Mar 14, 2002·Annals of Neurology·Manabu FunayamaFumiya Obata
Apr 12, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Ranjita BetarbetJ Timothy Greenamyre
May 16, 2002·Experimental Neurology·Eric K RichfieldHoward J Federoff
Jul 3, 2002·Nature Reviews. Neuroscience·M Angela CenciTimothy Schallert
Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jian WangLong Yu
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·William DauerRene Hen

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Citations

Sep 10, 2011·Journal of Neural Transmission·Bokyung ParkYoung J Oh
Jun 19, 2013·Brain Research·Nicola J RutherfordBenoit I Giasson
Jan 15, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cameron H GoodCarl R Lupica
Nov 9, 2011·The Neurologist·Maria Trinidad HerreroGurutz Linazasoro
Aug 7, 2012·Biochemistry. Biokhimii︠a︡·E V FilatovaP A Slominsky
Jun 8, 2010·Molecular Neurodegeneration·Wenjie LuoGabriela Chiosis
Dec 19, 2012·Alzheimer's Research & Therapy·Amanda N Sacino, Benoit I Giasson
Feb 19, 2011·Parkinson's Disease·Kemal Ugur TufekciKursad Genc
Mar 24, 2016·The AAPS Journal·Katelin E AhlersRory A Fisher
Nov 9, 2016·Frontiers in Molecular Biosciences·William T CarrickJannet Kocerha
Jul 17, 2013·Arquivos de neuro-psiquiatria·Gabriela S LongoDorotéia R S Souza
Nov 24, 2011·Experimental Neurobiology·Karen L O'Malley
Sep 16, 2017·Journal of Molecular Neuroscience : MN·Shay Ben-ShacharAvi Orr-Urtreger
Nov 1, 2017·Frontiers in Systems Neuroscience·Janna NiensThomas D Riemensperger
Apr 9, 2011·New Biotechnology·Pavan K Krishnamurthy, Einar M Sigurdsson

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