Parkinson's Disease in Pregnancy: A Case Report and Review of the Literature

Frontiers in Neurology
Sara OlivolaLorenza Driul

Abstract

Background: Pregnancy in Parkinson's disease is a rare occurrence, and to date, clinical experience with its management is rather limited. In clinical practice, doubts concern mainly the impact of PD on gestation, labor, and delivery as well as the safety of dopaminergic drugs. Case and review of the literature: We report the case of a 40-year-old woman with an 8-year history of PD. In the first trimester of her pregnancy, her motor status was similar to the pre-conceptional period. In gestation week 16, her motor status dramatically worsened and she complained of predictable "off" periods in the afternoon. For this reason, her dose of L-DOPA/carbidopa was increased up to 500/125 mg per day. At 39 gestational weeks, she gave birth to a healthy girl with an Apgar score of 9 by an uncomplicated cesarean delivery. The child was not breast fed to avoid exposure to antiparkinsonian drugs. The L-DOPA/carbidopa dosage remained constant during the postpartum period. We performed a systematic review of the literature using Ovid Medline, Scopus, and PubMed (including Cochrane database). We used the search terms "Parkinson disease" AND "pregnancy." We identified 20 studies of PD in pregnancy with a total of 37 pregnant women with PD. The ...Continue Reading

References

Jun 1, 1989·Clinical Neuropharmacology·H AllainG Defawe
Oct 1, 1988·Neurology·J F Kurtzke, I D Goldberg
Jul 1, 1987·Neurology·L I Golbe
Jan 1, 1985·Clinical Neuropharmacology·D G Cook, H L Klawans
Nov 1, 1970·Toxicology and Applied Pharmacology·C Lamar
Jan 1, 1995·Movement Disorders : Official Journal of the Movement Disorder Society·M C Ball, H J Sagar
Mar 1, 1993·Journal of Clinical Pharmacology·S Kacew
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·P HagellE Vinge
Feb 6, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·A Kupsch, W H Oertel
May 26, 1998·European Journal of Pharmacology·K A DisshonD E Dluzen
Jan 26, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·J Benito-LeónJ Porta-Etessam
May 5, 1999·Neurology·R Saunders-PullmanS Bressman
Jan 14, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·L M ShulmanW J Weiner
Mar 15, 2001·Parkinsonism & Related Disorders·R H. SwerdlowG F. Wooten
Mar 29, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Michele De MariPaolo Lamberti
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Marco MucchiutPaolo Bergonzi
Jul 8, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Michael Scott, Muhammad Chowdhury
May 9, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Jonas Lindh
Apr 2, 2008·Fertility and Sterility·Raimundo Nonato Campos-SousaBenedito Borges da Silva
May 27, 2008·Experimental Neurology·Heiko Braak, Kelly Del Tredici
Dec 18, 2008·Expert Review of Neurotherapeutics·Bradley J RobottomLisa M Shulman
May 5, 2009·Frontiers in Neuroendocrinology·Mélanie BourqueThérèse Di Paolo
Jun 16, 2009·Lancet·Andrew J LeesTamas Revesz
Jul 8, 2010·Journal of Human Reproductive Sciences·Baxi AshaPauranik Apoorva
Nov 3, 2010·Annual Review of Pathology·Joshua M ShulmanMel B Feany
Sep 20, 2012·Journal of the Neurological Sciences·Abdul Qayyum RanaMuhammad Saad Yousuf
Mar 13, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela BergGünther Deuschl
Sep 30, 2014·Parkinsonism & Related Disorders·Yair ZlotnikTanya Gurevich
May 31, 2017·Journal of Midwifery & Women's Health·Mary C Brucker, Tekoa L King

❮ Previous
Next ❯

Citations

Apr 30, 2020·International Journal of Environmental Research and Public Health·Fabiana CecchiniSerena Xodo
Jul 29, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·R García-RamosJ C Martínez Castrillo
May 16, 2021·Annals of the Academy of Medicine, Singapore·Yi Wen TayShen Yang Lim
Oct 9, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Francesca MagrinelliKailash P Bhatia

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

Ovid Medline
Scopus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Expert Review of Neurotherapeutics
Bradley J RobottomLisa M Shulman
Parkinsonism & Related Disorders
Mara Seier, Amie Hiller
Movement Disorders : Official Journal of the Movement Disorder Society
P HagellE Vinge
Movement Disorders : Official Journal of the Movement Disorder Society
Michele De MariPaolo Lamberti
International Journal of Clinical Practice
C D'SouzaB S Sastry
© 2021 Meta ULC. All rights reserved