Parkinson's disease research in a prospective cohort in China

Parkinsonism & Related Disorders
Honglei ChenGong Yang

Abstract

China has the largest population of Parkinson's disease (PD) patients; however few etiological studies of PD have been conducted in China. The Shanghai Women's Health Study recruited 74,941 women in urban Shanghai, aged 40 to 70, from 1996 to 2000. Self-reported PD cases were invited for a neurological examination and diagnoses were made by a movement disorder specialist. This cohort had very few smokers (2.7%), alcohol drinkers (2.3%), and post-menopausal hormone users (4.3%); however, tea drinking (29.9%) and exposure to tobacco smoke from husbands (61.8%) were common. A total of 301 participants reported PD diagnosis during the follow-up. The diagnosis was confirmed in 76 (57%) of the 133 clinically examined patients. An additional 19 (53%) PD cases were identified out of 36 participants who self-confirmed the diagnosis and provided a history on PD symptoms and treatments. As expected, increasing age was strongly associated with PD risk. Further, PD risk appears to be inversely associated with exposures to second-hand tobacco smoke from husbands and tea drinking, and positively with education, although none of these reached statistical significance. The age-adjusted odds ratio (OR) was 0.7 (95% confidence interval: 0.4-1.1) ...Continue Reading

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Citations

Oct 19, 2016·Lancet Neurology·Alberto Ascherio, Michael A Schwarzschild
Nov 21, 2017·Journal of Parkinson's Disease·Honglei Chen
May 31, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monira PervinYoriyuki Nakamura
May 28, 2020·International Journal of Molecular Sciences·Mark F McCarty, Aaron Lerner
Sep 4, 2016·Journal of Neural Transmission·Xiao-Lu NiuHe-Hua Li
Nov 10, 2018·Acta Neuropathologica Communications·Justin W NicholatosSergiy Libert
May 16, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Connie MarrasSamuel M Goldman
Apr 26, 2019·Annals of Clinical and Translational Neurology·Jennifer KizzaUNKNOWN China Kadoorie Biobank
Nov 1, 2020·Reviews on Environmental Health·Wei LiuWeihong Chen
Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ryuuta FukutomiMamoru Isemura
May 16, 2021·Journal of Chemical Neuroanatomy·Md Shahidul IslamSomayeh Ebrahimi-Barough
Apr 26, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Ming CaoPiu Chan

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