PMID: 11898537Mar 20, 2002Paper

Parkinson's disease: the treatment of drug-induced hallucinations and psychosis

Current Neurology and Neuroscience Reports
E S Molho, S A Factor

Abstract

Drug-induced psychosis is one of the most disabling complications of advancing Parkinson's disease. It has also been one of the most difficult to treat. Clozapine was the first medication shown to be safe and effective in this setting, and it remains the standard by which newer atypical antipsychotics are measured. However, due to the small but significant risk of agranulocytosis and the need for frequent blood testing, alternatives have been sought. Risperidone, olanzapine, and quetiapine are new atypical antipsychotics that have each been proposed as an alternative to clozapine, but the literature concerning their use in Parkinson's disease is conflicted and confusing. Although quetiapine appears to be the best current choice, none of these medications have equaled clozapine's ability to safely treat drug-induced psychosis without the risk of worsening parkinsonism.

References

Jan 1, 1977·Transactions of the American Neurological Association·H L KlawansW J Weiner
Jun 1, 1978·The American Journal of Psychiatry·C MoskovitzH L Klawans
Jul 1, 1991·Journal of the American Geriatrics Society·J L Cummings
Aug 1, 1989·Annals of Internal Medicine·W E GoldenW S Metzer
Sep 1, 1989·Neurology·J H Friedman, M C Lannon
Jan 1, 1985·European Archives of Psychiatry and Neurological Sciences·E Scholz, J Dichgans
May 1, 1985·Archives of Internal Medicine·J H Friedman
Dec 27, 1971·JAMA : the Journal of the American Medical Association·F K Goodwin
Sep 3, 1994·Lancet·B FordP Greene
Sep 9, 1995·Lancet·I G McKeithR W Harrison
Jul 15, 1993·The New England Journal of Medicine·J M AlvirJ A Schaaf
Dec 1, 1996·Archives of Neurology·J R Sanchez-RamosG W Paulson
Jul 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·S A Factor, J H Friedman
Jul 1, 1997·Movement Disorders : Official Journal of the Movement Disorder Society·G MecoV Bonifati
Feb 3, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·R H WorkmanM E Kunik
May 5, 1998·Neurology·F J Jiménez-JiménezJ A Molina
May 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·R InzelbergA D Korczyn
Jun 3, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·D M RoaneT E Feinberg
Jun 3, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·M A Parsa, B Bastani
Nov 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·J M GrahamH J Sagar
Mar 11, 1999·The New England Journal of Medicine·UNKNOWN Parkinson Study Group
May 29, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·H H FernandezM Rosenfeld
Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·E S Molho, S A Factor
Feb 1, 2000·Journal of Clinical Psychopharmacology·S D Targum, J L Abbott
Apr 7, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J H Friedman, S A Factor
Apr 7, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·N A Leopold
Dec 5, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·E MohrP P De Deyn

❮ Previous
Next ❯

Citations

Dec 11, 2003·Current Treatment Options in Neurology·Victoria S. Pelak, Grant T. Liu
Dec 31, 2002·Psychoneuroendocrinology·J H Friedman
Sep 23, 2003·Parkinsonism & Related Disorders·Kazumichi YamadaYukitaka Ushio
Dec 5, 2003·Journal of Geriatric Psychiatry and Neurology·Jacobo Mintzer, Steven D Targum
Dec 7, 2007·Expert Review of Neurotherapeutics·Marco OnofrjLaura Bonanni

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

The Annals of Pharmacotherapy
James J Gugger, Mary L Wagner
Movement Disorders : Official Journal of the Movement Disorder Society
R DjaldettiE Melamed
Movement Disorders : Official Journal of the Movement Disorder Society
C G GoetzS Leurgans
Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
A CannasM Giagheddu
© 2022 Meta ULC. All rights reserved