PMID: 9179765Jun 1, 1997Paper

Parkville virus: a novel genetic variant of human calicivirus in the Sapporo virus clade, associated with an outbreak of gastroenteritis in adults

Journal of Medical Virology
J S NoelS S Monroe

Abstract

This report describes the characterization of Parkville virus, the etiologic agent of an outbreak of foodborne gastroenteritis, that has the morphology of a calicivirus and genetic properties that distinguish it from previously identified strains in the Sapporo/Manchester virus clade. Sequence analysis of the Parkville virus genome showed it contained the RNA-dependent RNA polymerase motifs GLPSG and YGDD characteristic of members of the family Caliciviridae with an organization identical to that reported for the Manchester virus where the capsid region of the polyprotein is fused to the RNA polymerase. Parkville virus however, demonstrates considerable sequence divergence from both the Manchester and Sapporo caliciviruses, providing the first indications that genetic diversity exists within caliciviruses of this previously homogeneous clade. On the basis of recent advances in the genetic characterization of members of the family Caliciviridae, we propose a new interim phylogenetic classification system in which Parkville virus would be included with Manchester and Sapporo virus as a separate group distinct from the small round-structured viruses (Norwalk-like viruses) that also cause diarrhea in humans.

Citations

Nov 1, 2002·Journal of Clinical Microbiology·Roxane Chikhi-BrachetEvelyne Kohli
Apr 9, 2004·Journal of Clinical Microbiology·Chris I GallimoreDavid W G Brown
May 28, 2004·Journal of Virology·Rong ChenB V Venkataram Prasad
May 28, 2005·Journal of Virology·Tomoichiro OkaNaokazu Takeda
Dec 8, 2005·Journal of Clinical Microbiology·Qiu-Hong WangLinda J Saif
Dec 25, 2007·Applied and Environmental Microbiology·Roman BuckowAnselm Lehmacher
Feb 22, 2008·Journal of Clinical Microbiology·Khira Sdiri-LouliziPierre Pothier
Jul 5, 2008·Emerging Infectious Diseases·Fang-Tzy WuChen-Fu Yang
Sep 27, 2013·BMC Infectious Diseases·Rachel M LeeDerek A T Cummings
Feb 19, 2010·Journal of Medical Virology·Yasutaka YamashitaTomoichiro Oka
Aug 5, 2008·Virus Research·Grant S HansmanNaokazu Takeda
Sep 16, 2016·PloS One·Siwar AyouniAlexis de Rougemont
Jan 6, 2015·Risk Analysis : an Official Publication of the Society for Risk Analysis·Travis MinorDavid Zorn

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