Parotid fluid cortisol and cortisone

The Journal of Clinical Investigation
F H KATZ, I L SHANNON

Abstract

Parotid fluid corticosteroids, substantially comprised of cortisol and cortisone, were previously demonstrated to rise to far greater levels 4 hr after administration of ACTH than they did in the third trimester of pregnancy, although the plasma total corticosteroid concentrations were similar in these two states. It was therefore suggested that only nonproteinbound corticosteroid gains access to parotid fluid. In the present study parotid fluid cortisol and cortisone and plasma dialyzable cortisol concentrations have been measured in normal men before and 2 hr after 40 U ACTH, and, in another group, before and after 10 days of diethystilbestrol (5 mg daily). Total plasma cortisol rose from a mean of 6.3 to 17.9 mug/100 ml after ACTH and from 14.6 to 39.4 mg/100 ml after the estrogen. However parotid fluid cortisol plus cortisone rose from 0.8 to 2.6 mug/100 ml after ACTH and to only 2.2 after estrogen. This rise resembled that of the plasma dialyzable cortisol (control 0.4, ACTH 1.8, estrogen 1.2 mug/100 ml) rather than the increase in total plasma cortisol which was over twice as high after estrogen as after ACTH. Thus parotid fluid corticosteroids seem to be a good measure of nonprotein-bound corticosteroid, the cortisol ava...Continue Reading

References

Jan 1, 1976·Experientia·A D LandmanE T Pritchard
Jun 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·P M MeulenbergT J Benraad
Aug 15, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·P BoluferP Antonio
Jan 1, 1980·Journal of Steroid Biochemistry·M LuisiF Franchi
Oct 1, 1981·Journal of Steroid Biochemistry·M LuisiM Gasperi
Nov 1, 1984·Psychiatry Research·M AnsseauE Demey-Ponsart
Aug 15, 2012·Nature Reviews. Endocrinology·Ilias PerogamvrosPeter J Trainer
Mar 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·I D Mandel
Feb 18, 1994·Annals of the New York Academy of Sciences·P T Ellison
Dec 1, 1990·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·E P Meulenberg, J A Hofman
Jul 3, 2010·Psychosomatic Medicine·Thomas Remer, Lijie Shi
Jun 11, 2009·Clinical Endocrinology·Phillipa C RainsKim C Donaghue
Sep 1, 1973·Archives of Oral Biology·D B FergusonA J Potts
Apr 5, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Joanne BlairRichard Ross
Sep 20, 1993·Annals of the New York Academy of Sciences·G F Read
Jul 1, 1980·British Journal of Obstetrics and Gynaecology·J J EvansA Y Merrick
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·R F Vining, R A McGinley
May 20, 2020·The Journal of Clinical Endocrinology and Metabolism·Nandini PrasadAbilash Nair
Mar 1, 1982·Pharmazie in unserer Zeit·B Mühlenbruch

Citations

Jan 1, 1966·The Journal of Clinical Endocrinology and Metabolism·I L SHANNONF H KATZ
Sep 1, 1966·The Journal of Clinical Endocrinology and Metabolism·I L SHANNONR L Jenson
Apr 1, 1967·The Journal of Clinical Endocrinology and Metabolism·D N OrthG W Liddle
Feb 1, 1959·The Journal of Clinical Investigation·W R SLAUNWHITE, A A SANDBERG
Jun 1, 1960·The Journal of Clinical Investigation·A G FRANTZJ W JAILER
Oct 1, 1961·The Journal of Clinical Endocrinology and Metabolism·A G FRANTZJ W JAILER
Jul 1, 1962·Journal of Dental Research·I L SHANNONH H CHAUNCEY
Mar 23, 1962·Science·W R SLAUNWHITEA A SANDBERG
Jun 1, 1964·The Journal of Clinical Investigation·J E PLAGERW J STAUBITZ
Jul 1, 1964·Acta Endocrinologica·F H KATZ, I L SHANNON
Nov 1, 1959·The Journal of Clinical Endocrinology and Metabolism·I L SHANNONR P FELLER

Related Concepts

Cortisone Reductase Deficiency
Periodicity
Plasma Protein Binding Capacity
Parotid Gland
Adreson
Saliva
POMC
Distilbène
Oradexon
Corticotropin

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.