Parotid gland mean dose as a xerostomia predictor in low-dose domains

Acta Oncologica
Hubert Szymon GabryśMark Bangert

Abstract

Xerostomia is a common side effect of radiotherapy resulting from excessive irradiation of salivary glands. Typically, xerostomia is modeled by the mean dose-response characteristic of parotid glands and prevented by mean dose constraints to either contralateral or both parotid glands. The aim of this study was to investigate whether normal tissue complication probability (NTCP) models based on the mean radiation dose to parotid glands are suitable for the prediction of xerostomia in a highly conformal low-dose regime of modern intensity-modulated radiotherapy (IMRT) techniques. We present a retrospective analysis of 153 head and neck cancer patients treated with radiotherapy. The Lyman Kutcher Burman (LKB) model was used to evaluate predictive power of the parotid gland mean dose with respect to xerostomia at 6 and 12 months after the treatment. The predictive performance of the model was evaluated by receiver operating characteristic (ROC) curves and precision-recall (PR) curves. Average mean doses to ipsilateral and contralateral parotid glands were 25.4 Gy and 18.7 Gy, respectively. QUANTEC constraints were met in 74% of patients. Mild to severe (G1+) xerostomia prevalence at both 6 and 12 months was 67%. Moderate to severe...Continue Reading

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Citations

Dec 4, 2019·Australasian Physical & Engineering Sciences in Medicine·Ming ChaoJosé A Peñagarícano
Aug 17, 2019·Frontiers in Oncology·Rosario AstaburuagaMark Bangert
Mar 5, 2020·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Julia Stephanie BrunoEduardo Rodrigues Fregnani
Apr 28, 2019·Seminars in Radiation Oncology·Jolien Heukelom, Clifton David Fuller

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