PMID: 15374194Jan 1, 1996Paper

Parotid gland secretion of the aging rat

Archives of Gerontology and Geriatrics
L Bodner, M Gorsky

Abstract

Saliva secretion stimulated by alpha adrenergic beta adrenergic and muscarinic cholinergic neurotransmitters was evaluated in young adult and old rats. Parotid saliva was collected following methoxamin (METH) (6 mg/kg), isoproterenal (ISO) (30 mg/kg), or pilocarpin (PILO) (7.5 mg/kg) as secretory stimuli. The flow rate and the concentrations of protein, Na+ and K+ were measured. Saliva flow rate was 40%-50% lower (P < 0.01) in old rats following METH and PILO, but there was no difference following ISO stimulation. Saliva of old rats stimulated by METH or PILO contained about 30%-40% more (P < 0.01) protein. Comparable protein levels were in saliva stimulated by ISO. No changes were found in Na+ and K+ concentrations in all saliva samples. These results suggest that the age-related alteration in flow rate is not a general phenomenon, but rather specific and limited to the high flow rate stimulants (alpha-adrenergic and muscarinic-cholinergic). Transport alteration from the circulatory system into the parotid gland may be the underlying mechanism.

References

Jan 1, 1991·Experimental Gerontology·L BodnerI Hammel
Apr 1, 1989·International Journal of Radiation Biology·L Bodner
Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·B J BaumG S Roth
Feb 1, 1987·Journal of Dental Research·I D Mandel
Feb 1, 1985·International Journal of Oral Surgery·K YaegakiC Sujaku
Sep 1, 1985·Mechanisms of Ageing and Development·L Bodner, B J Baum
Jan 1, 1971·Scandinavian Journal of Dental Research·P Arneberg
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·L Bodner, B J Baum
Feb 1, 1981·The Australian Journal of Experimental Biology and Medical Science·J A Young, C A Schneyer
Sep 1, 1984·Journal of Dental Research·H Ben-AryehD Gutman
Jul 1, 1981·Journal of Dental Research·B J Baum
Aug 1, 1994·Journal of Dental Research·R S PercivalP D Marsh
Jan 1, 1993·Archives of Oral Biology·L BodnerI Hammel

❮ Previous
Next ❯

Citations

Sep 20, 2005·Medical Molecular Morphology·Masafumi MimuraTeruo Amagasa
Dec 31, 2003·Archives of Gerontology and Geriatrics·Nili GrossmanLipa Bodner
Jul 26, 2008·Archives of Gerontology and Geriatrics·L BodnerI Kaffe
Sep 27, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Lipa Bodner
Jul 26, 2012·Oxidative Medicine and Cellular Longevity·Junyang JungYoungbuhm Huh
Jun 1, 2010·Journal of Child Language·Martine A R GijselAnna M T Bosman
Aug 6, 1999·The Journal of Laryngology and Otology·L Bodner

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Archives of Gerontology and Geriatrics
L BodnerI Kaffe
Oral Surgery, Oral Medicine, and Oral Pathology
L H GUERNSEY
© 2021 Meta ULC. All rights reserved