Parotid gland volumetric changes during intensity-modulated radiotherapy in head and neck cancer.

The British Journal of Radiology
Alba FiorentinoVincenzo Fusco

Abstract

To evaluate volumetric changes of parotid glands (PGs) during intensity-modulated radiotherapy (IMRT) in head and neck cancer patients. During IMRT all patients underwent kilovolt cone-beam CT (CBCT) scans to verify the set-up positioning in a protocol study. On each CBCT scan, the PGs were retrospectively contoured and evaluated with a dose-volume histogram. From February to June 2011, 10 patients were enrolled. 140 CBCT scans were registered (280 PGs): for each patient, a median of 14 CBCT scans were performed (range 14-16). At the start of radiation, the average volume for ipsilateral PGs (iPGs) was 18.77 ml (range 12.9-31.2 ml), whereas for contralateral PGs (cPGs) it was 16.63 ml (range 8.3-28.7 ml). At the last CBCT scan, the average volume loss was 43.5% and 44.0% for the iPG and cPG, respectively. When we analysed the percentage of volume loss, we observed that the volume decreased by linear regression (r(2)=0.92 for iPG; r(2)=0.91 for cPG), with an average volume loss rate of 1.5% per day for both PGs. During the third week of treatment the volume of both PGs reduced by 24-30%. Our data show that, during IMRT, the shrinkage of PGs should be taken into account. A replan could be indicated in the third week of radiotherapy.

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Citations

Dec 18, 2013·La Radiologia medica·Alba FiorentinoVincenzo Fusco
Apr 24, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Maria Luisa BelliGiovanni Mauro Cattaneo
Sep 14, 2013·The British Journal of Radiology·G SanguinetiT McNutt
Oct 16, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A FiorentinoV Fusco
Mar 7, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M FaruoloV Fusco
Jun 22, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Charlotte L BrouwerNanna M Sijtsema
Apr 4, 2015·International Journal of Radiation Oncology, Biology, Physics·Mei FengX Allen Li
Oct 12, 2015·Archives of Oral Biology·Monique Dossena AcauanFernanda Gonçalves Salum
Mar 13, 2014·Journal of Periodontal & Implant Science·Min ZhengXin-Hua Liang
Jan 16, 2020·Cancers of the Head & Neck·Howard E Morgan, David J Sher
Jul 29, 2020·Journal of Cancer Research and Therapeutics·Bhargavi IlangovanSubathira Balasundaram
Aug 17, 2019·Frontiers in Oncology·Rosario AstaburuagaMark Bangert
Nov 13, 2020·BJR Open·Loïg VaugierEmmanuel Jouglar

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