PMID: 15241233Jul 9, 2004Paper

Paroxetine, a selective serotonin reuptake inhibitor, reduces depressive symptoms and subjective handicaps in patients with dizziness

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Arata HoriiTakeshi Kubo

Abstract

When treating dizzy patients, the psychiatric aspect should be carefully addressed regardless of whether a well-defined organic disease is present. In this prospective study, we aimed to elucidate the role of paroxetine, a selective serotonin reuptake inhibitor, in the treatment of dizziness. Forty-seven patients who complained of dizziness were treated with 20 mg of paroxetine per day. The depressive state of the patient was evaluated by the Zung Self-Rating Depression Scale (SDS). Treatment outcomes were measured with self-assessment of subjective handicaps in daily life using a dizziness and unsteadiness questionnaire. The questionnaire consisted of five factors related to emotional or bodily dysfunction that could be affected by dizziness. Changes in Self-Rating Depression Scale scores and subjective handicaps were assessed at 4 and 8 weeks after the start of paroxetine. In patients having well-defined organic diseases with high Self-Rating Depression Scale scores, paroxetine improved all five subjective handicap factors as well as Self-Rating Depression Scale scores. The decline in Self-Rating Depression Scale scores showed a significant correlation with improvement of subjective handicaps, which was related to emotional p...Continue Reading

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Citations

Jan 13, 2006·Journal of Psychopharmacology·Renato T Ramos
Aug 2, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sirpa KetolaErna Kentala
Oct 6, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Aaron Trinidade, Joel A Goebel
Jan 18, 2006·Current Opinion in Neurology·Jeffrey P Staab
Aug 19, 2020·The Laryngoscope·Alicia WangJacob R Brodsky
Oct 14, 2018·Current Treatment Options in Neurology·Stoyan PopkirovDagny Holle-Lee
Mar 8, 2011·Expert Review of Neurotherapeutics·Carey D BalabanJoseph M Furman
Jul 27, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G M DiukovaS A Makarov
Jul 10, 2016·Journal of Vestibular Research : Equilibrium & Orientation·Arata HoriiHidenori Inohara
Jan 24, 2014·Nihon Jibiinkoka Gakkai kaiho·Noriaki Takeda
Apr 30, 2019·Expert Opinion on Pharmacotherapy·Andreas ZwergalThomas Brandt
Jul 27, 2021·Otolaryngologic Clinics of North America·Wendy J CarenderSteven A Telian
Jul 1, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Alicia WangJacob R Brodsky

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