Paroxetine controlled release in the treatment of menopausal hot flashes: a randomized controlled trial

JAMA : the Journal of the American Medical Association
Vered StearnsEric Dube

Abstract

Standard therapy for hot flashes has been hormone replacement with estradiol or progestational agents, but recent data suggest that antidepressants inhibiting serotonin reuptake may also be effective. To evaluate a selective serotonin reuptake inhibitor (paroxetine controlled release [CR]) in treating the vasomotor symptoms displayed by a general cross-section of menopausal women. Randomized, double-blind, placebo-controlled, parallel group study conducted across 17 US sites, including urban, suburban, and rural clinics. A total of 165 menopausal women aged 18 years or older experiencing at least 2 to 3 daily hot flashes and must have discontinued any hormone replacement therapy for at least 6 weeks. Women were excluded if they had any signs of active cancer or were undergoing chemotherapy or radiation therapy. After a 1-week placebo run-in phase, study participants were randomized to receive placebo or receive 12.5 mg/d or 25.0 mg/d of paroxetine CR (in a 1:1:1 ratio) for 6 weeks. Mean change from baseline to week 6 in the daily hot flash composite score (frequency x severity). Fifty-six participants were randomly assigned to receive placebo and 51 to receive 12.5 mg/d and 58 to receive 25.0 mg/d of paroxetine CR. The mean red...Continue Reading

Citations

Jul 28, 2013·Journal of General Internal Medicine·Taghreed ShamsMazen Ferwana
Jan 23, 2014·Menopause : the Journal of the North American Menopause Society·Claudio N Soares
Dec 26, 2006·Pharmacogenomics·Justin StebbingNancy E Davidson
Jan 31, 2012·Asian Journal of Andrology·Jason M JonesCharles L Loprinzi
Sep 10, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Robert R Freedman
Aug 19, 2014·BMC Cancer·Yuriy ShapovalovEdward B Brown
Feb 27, 2014·Menopause : the Journal of the North American Menopause Society·James A SimonAndrew E Denker
Mar 24, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Brigitte L Sicat
Feb 21, 2014·Menopause : the Journal of the North American Menopause Society·David J PortmanJoel Lippman
Oct 17, 2014·Cancer Chemotherapy and Pharmacology·Joel M ReidMatthew M Ames
Jul 1, 2006·Women's Health·Deborah R Kim, Hadine Joffe
Jul 10, 2009·Women's Health·JoAnn V PinkertonRebecca S Kightlinger
Oct 2, 2004·Obstetrics and Gynecology·UNKNOWN American College of Obstetricians and Gynecologists Women's Health Care Physicians
May 4, 2004·Obstetrics and Gynecology·E W FreemanL Sheng
Dec 31, 2004·Obstetrics and Gynecology·Michele L EvansRobert B Jaffe
Jun 4, 2005·Obstetrics and Gynecology·Natalie Meirowitz
Apr 3, 2007·Obstetrics and Gynecology·Deborah GradyGeorge F Sawaya
Sep 27, 2006·Journal of Women's Health·Marlene P FreemanBarbara H Brumbach
Mar 6, 2010·Journal of Women's Health·Thomas Guttuso, Michele Evans
Nov 30, 2007·Journal of General Internal Medicine·Jennifer R ZebrackAnn B Nattinger
Jan 6, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Roger S McIntyreSidney H Kennedy
Aug 4, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Wendy L Wolfman
Jun 6, 2007·BioPsychoSocial Medicine·Akira OishiNoriyuki Inaba
Jan 22, 2008·Menopause : the Journal of the North American Menopause Society·Rebecca C ThurstonKaren A Matthews
May 29, 2008·The Journal of Clinical Psychiatry·Emma M SteinbergPeter J Schmidt
Jun 4, 2008·Menopause : the Journal of the North American Menopause Society·Rebecca C ThurstonKaren A Matthews
Jan 9, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·C L LoprinziT R Fitch
Feb 4, 2009·Menopause : the Journal of the North American Menopause Society·Aditya BardiaCharles Loprinzi
Apr 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L LoprinziPaul Novotny
Nov 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L LoprinziKelli N Burger
Dec 17, 2009·Journal of General Internal Medicine·Gerald W Smetana, Jane S Sillman
Sep 21, 2010·Clinical Interventions in Aging·Sebastián Carranza-Lira
Jul 9, 2011·Menopause : the Journal of the North American Menopause Society·Gregory A PlotnikoffDavid M Radosevich
Oct 13, 2011·BMC Complementary and Alternative Medicine·Gary R ElkinsAimee K Johnson
Feb 26, 2013·Menopause : the Journal of the North American Menopause Society·Gary R ElkinsTimothy Z Keith
Mar 25, 2004·Journal of Pain and Symptom Management·Thomas Guttuso
Nov 23, 2006·Breast Cancer Research and Treatment·Matthew P GoetzJames N Ingle
Sep 19, 2007·Breast Cancer Research and Treatment·David Cella, Lesley J Fallowfield
Jan 13, 2004·Menopause : the Journal of the North American Menopause Society·Sophie Desindes
Jan 13, 2004·Menopause : the Journal of the North American Menopause Society·UNKNOWN North American Menopause Society
Jan 26, 2005·Menopause : the Journal of the North American Menopause Society·Nancy King Reame
Jan 26, 2005·Menopause : the Journal of the North American Menopause Society·Eila Suvanto-LuukkonenJuha S Tapanainen
May 10, 2005·Menopause : the Journal of the North American Menopause Society·Ellen W FreemanTahmina Ferdousi
May 10, 2005·Menopause : the Journal of the North American Menopause Society·Samantha A MillerEllie E Schoenbaum

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