Paroxysmal cold haemoglobinuria as a tardive complication of idiopathic myelofibrosis

European Journal of Haematology
Massimo BrecciaGiuliana Alimena

Abstract

Paroxysmal cold haemoglobinuria (PCH) is an autoimmune haemolytic anaemia caused by the Donath-Landsteiner antibody. It is classically described in association with chronic syphilis or after acute viral infections. We describe the first case of PCH presented as a late manifestation of advanced myelofibrosis associated with antiphospholipid syndrome, that promptly responded to high dosage of prednisone.

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Citations

Jun 15, 2007·British Journal of Haematology·Morie A Gertz
Jun 5, 2015·Hematology/oncology Clinics of North America·Satish Shanbhag, Jerry Spivak
Nov 4, 2016·Transfusion·Michelle P ZellerNancy M Heddle

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