Paroxysmal tonic upgaze: a reappraisal of outcome

Annals of Neurology
M HaymanL K Shield

Abstract

Paroxysmal tonic upgaze (PTU) of childhood is a distinctive neuro-ophthalmological syndrome of unknown etiology and pathogenesis that is characterized by episodes of sustained upward deviation of the eyes, often with incomplete downward saccades on attempted downgaze. It is generally regarded as having a benign outcome. We observed 16 children with PTU, from 10 months to 11 years from onset (mean, 5.4 years), to study the natural history and possible etiology. Five cases were from two unrelated families. Onset of PTU occurred either during or after an intercurrent infection or vaccination in 5 children. No antecedent was identifiable in the rest. PTU had completely resolved in 10 children (62%) (mean age at offset, 2.5 years), whereas 2 children intermittently manifest a modified form of the disorder. At follow-up, 11 children (69%) had developmental delay, intellectual disability, or language delay and 9 (56%) had ocular motility problems other than PTU. Only 3 children (19%) had normal development and neurological findings. PTU is a heterogeneous syndrome with respect to associations and outcome and may simply be an age-dependent manifestation of a variety of disorders affecting corticomesencephalic control of vertical eye mo...Continue Reading

References

Jan 1, 1978·Archives of Neurology·G M HalmagyiJ M Hallinan
Jun 1, 1992·Clinical Neuropharmacology·M R Pranzatelli
Mar 1, 1992·Pediatric Neurology·B Echenne, F Rivier
Aug 1, 1992·Pediatric Clinics of North America·H T Chugani
Nov 1, 1990·Neuropediatrics·T DeonnaH U Meyer
Apr 1, 1990·Archives of Ophthalmology·M Mets
Jan 1, 1989·Archives of Ophthalmology·J C AhnC S Hoyt
Jul 1, 1988·Journal of Child Neurology·R A Ouvrier, F Billson
Dec 1, 1987·Pediatric Clinics of North America·C S Hoyt
May 1, 1988·Journal of Neuropathology and Experimental Neurology·H C KinneyF H Gilles
Oct 1, 1987·Annals of Neurology·H T ChuganiJ C Mazziotta
Jul 1, 1987·Annals of Neurology·R J LeighR H Civil
Oct 1, 1985·Neurology·S E ThurstonI Osorio
Jan 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·J A SharpeW A Fletcher
Jul 1, 1973·Journal of Neurophysiology·A A Skavenski, D A Robinson
May 1, 1980·American Journal of Ophthalmology·C S HoytA A Weber
Apr 1, 1995·Developmental Medicine and Child Neurology·H SugieY Matsui
Jul 1, 1995·Journal of Child Neurology·R D ShethJ B Bodensteiner
May 1, 1995·Developmental Medicine and Child Neurology·N Gordon
Oct 1, 1994·Neurology·E AndermannD Arnold
May 1, 1993·Developmental Medicine and Child Neurology·J CampistolC Garaizar
May 1, 1993·The Journal of Pediatrics·M BourgeoisF Goutières
Mar 1, 1993·Pediatric Neurology·M A Gieron, J K Korthals
Dec 1, 1995·Developmental Medicine and Child Neurology·J D ReerinkJ H Ruys
Nov 1, 1955·American Journal of Ophthalmology·J E LEBENSOHN

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Next ❯

Citations

Jun 22, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Cecilia BonnetEmmanuel Roze
May 18, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Cinzia SalminaGian Paolo Ramelli
Jul 11, 2009·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Alberto VerrottiFrancesco Chiarelli
Dec 2, 2006·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A RoubertieB Echenne
Dec 7, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Lubov BlumkinTally Lerman-Sagie
Mar 2, 2005·Brain & Development·Robert Ouvrier, Frank Billson
Jan 18, 2015·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Lubov BlumkinTally Lerman-Sagie
Dec 3, 2014·Pediatric Neurology·Shinobu FukumuraHiroyuki Tsutsumi
Jan 27, 2009·Journal of Child Neurology·Nesrin SenbilYavuz Gürer
Mar 30, 2005·Journal of Child Neurology·Kevin JosephMarc Difazio
Jun 22, 2018·Developmental Medicine and Child Neurology·Véronique HumbertclaudeUNKNOWN Episodic Syndromes Consortium
Jan 21, 2000·Journal of Child Neurology·A SpaliceP Iannetti
Dec 12, 2020·The Journal of Pediatrics·Deepa Sirsi, Dallas Armstrong
Feb 14, 2021·Pediatric Neurology·Raffaele FalsaperlaGiovanni Corsello
Aug 14, 2003·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·F Rouveyrol, J L Stephan

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