PARP-1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population.

Molecular Biology Reports
Quanbao ZhangWenzhen Yuan

Abstract

PARP-1 plays important role in the BER (base excision repair) and maintenance of genomic integrity. Previous study found the Val762Ala genetic variant in the PARP-1 gene contributed to susceptibility of some cancers and decreased PARP-1 enzyme activity in response to oxidative damage. Helicobacter pylori (H. pylori) infection was thought to be one of the major causes of gastric cancer. In this study, we investigated the association between the PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection, and the risk for gastric cancer. This hospital-based, case-control study was performed involving 556 individuals (236 cases with gastric cancer and 320 controls without evidence of neoplasm and gastrointestinal disease) using a PCR-RFLP method. Chi-square test and logistic regression analysis were used to count OR and 95% CI. 762Ala/Ala genotype was overrepresented in the cases (16.9%) compared with controls (10.3%), (OR, 1.942; 95% CI, 1.157-3.257, P = 0.011). Multivariate analysis showed that two factors were significantly associated with risk of gastric cancer, including CagA(+) H. pylori infection (OR, 2.562; 95% CI, 1.174-5.240, P = 0.037), PARP-1 762AA genotype (OR, 1.772; 95% CI, 1.065-3.867; P = 0.042). Stratification ana...Continue Reading

References

Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M Simbulan-RosenthalM E Smulson
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A A PieperA Verma
Nov 30, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F CottetM L Muiras
Feb 22, 2001·Science·R D WoodT Lindahl
Apr 3, 2001·Journal of Clinical Microbiology·C FigueiredoL J van Doorn
Jul 30, 2002·Gastroenterology·Jae J KimAntonia R Sepulveda
Sep 12, 2002·Pharmacological Reviews·László Virág, Csaba Szabó
Jan 16, 2004·Gastroenterology·Jia Qing HuangRichard H Hunt
Feb 15, 2005·Japanese Journal of Clinical Oncology·Motoko ShiokawaHitoshi Nakagama
Sep 6, 2005·Genes & Development·Mi Young KimW Lee Kraus

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Citations

Mar 1, 2012·Journal of Surgical Oncology·Isabelle Joyce de Lima Silva-FernandesSilvia Helena Barem Rabenhorst
Apr 22, 2017·World Journal of Gastroenterology : WJG·Mohammad YaghoobiRichard H Hunt
Jan 10, 2012·Molecular Diagnosis & Therapy·Wenting HeYumin Li
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xiong-Fei PanChun-Xia Yang
Oct 11, 2012·Oxidative Medicine and Cellular Longevity·Aswin Mangerich, Alexander Bürkle
Jun 22, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Augusto NogueiraRui Medeiros
Nov 24, 2011·Current Microbiology·Hua WangShihe Shao
May 2, 2013·Molecular Diagnosis & Therapy·Andrzej RoszakPaweł P Jagodziński
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Yuan-Yuan WenChun-Xia Yang
Nov 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yue HuLi Liu
Feb 2, 2013·Molecular Aspects of Medicine·Nicola J Curtin, Csaba Szabo

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