Abstract
PARP-1 plays important role in the BER (base excision repair) and maintenance of genomic integrity. Previous study found the Val762Ala genetic variant in the PARP-1 gene contributed to susceptibility of some cancers and decreased PARP-1 enzyme activity in response to oxidative damage. Helicobacter pylori (H. pylori) infection was thought to be one of the major causes of gastric cancer. In this study, we investigated the association between the PARP-1 Val762Ala polymorphism, CagA(+) H. pylori infection, and the risk for gastric cancer. This hospital-based, case-control study was performed involving 556 individuals (236 cases with gastric cancer and 320 controls without evidence of neoplasm and gastrointestinal disease) using a PCR-RFLP method. Chi-square test and logistic regression analysis were used to count OR and 95% CI. 762Ala/Ala genotype was overrepresented in the cases (16.9%) compared with controls (10.3%), (OR, 1.942; 95% CI, 1.157-3.257, P = 0.011). Multivariate analysis showed that two factors were significantly associated with risk of gastric cancer, including CagA(+) H. pylori infection (OR, 2.562; 95% CI, 1.174-5.240, P = 0.037), PARP-1 762AA genotype (OR, 1.772; 95% CI, 1.065-3.867; P = 0.042). Stratification ana...Continue Reading
References
Mar 1, 1997·Gut·J ParsonnetH Vogelman
Jan 1, 1997·Developmental Genetics·K S WangR B Hodgetts
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M Simbulan-RosenthalM E Smulson
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A A PieperA Verma
Nov 30, 2000·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·F CottetM L Muiras
Feb 22, 2001·Science·R D WoodT Lindahl
Apr 3, 2001·Journal of Clinical Microbiology·C FigueiredoL J van Doorn
Jun 20, 2001·Gut·M KiddJ A Louw
Sep 5, 2001·Journal of Clinical Pathology·S S YeaK H Paik
Jul 30, 2002·Gastroenterology·Jae J KimAntonia R Sepulveda
Sep 12, 2002·Pharmacological Reviews·László Virág, Csaba Szabó
Feb 1, 2003·Molecular Pathology : MP·C I KoehlerM Odenthal
Jan 16, 2004·Gastroenterology·Jia Qing HuangRichard H Hunt
Feb 6, 2004·Nucleic Acids Research·Silke SüsseLisa Wiesmüller
Mar 18, 2004·Cancer Research·Yong ZhuXifeng Wu
Jun 19, 2004·Cancer Research·Bingtao HaoFuchu He
Sep 3, 2004·Cancer Research·Kristin L LockettJennifer J Hu
Feb 15, 2005·Japanese Journal of Clinical Oncology·Motoko ShiokawaHitoshi Nakagama
Feb 16, 2005·Gut·M OhyauchiT Shimosegawa
Sep 6, 2005·Genes & Development·Mi Young KimW Lee Kraus
Citations
May 15, 2012·Journal of Basic Microbiology·Neng LiFeifei She
Sep 16, 2010·Molecular Biology Reports·Ziping ChenXiaoli Cheng
May 27, 2011·DNA and Cell Biology·JiHye KimKyuBum Kwack
Nov 15, 2011·Molecular and Cellular Biochemistry·Xiangting ZengJunqiang Zhang
Mar 1, 2012·Journal of Surgical Oncology·Isabelle Joyce de Lima Silva-FernandesSilvia Helena Barem Rabenhorst
Oct 18, 2012·Molecular Biology Reports·Noel PabalanHilmi Ozcelik
Nov 30, 2016·Oncology Letters·Ying LiuHui Liu
Apr 22, 2017·World Journal of Gastroenterology : WJG·Mohammad YaghoobiRichard H Hunt
Apr 7, 2010·Molecular Biology Reports·Zhu Ke-XiangLiu Tao
Jan 10, 2012·Molecular Diagnosis & Therapy·Wenting HeYumin Li
May 13, 2011·Molecular Biology Reports·Zhu Ke-XiangLiu Tao
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Xiong-Fei PanChun-Xia Yang
Aug 15, 2014·Experimental and Therapeutic Medicine·Hao JiangHongjuan Ouyang
Oct 11, 2012·Oxidative Medicine and Cellular Longevity·Aswin Mangerich, Alexander Bürkle
Jun 22, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Augusto NogueiraRui Medeiros
Apr 2, 2010·Molecular Biology Reports·Qiao ZhongShuwei Tian
Nov 24, 2011·Current Microbiology·Hua WangShihe Shao
Dec 1, 2011·Genetic Epidemiology·Hongping YuQingyi Wei
Feb 4, 2014·PloS One·Rui-Xi HuaXiang-Zhou Sun
May 2, 2013·Molecular Diagnosis & Therapy·Andrzej RoszakPaweł P Jagodziński
Mar 30, 2010·Molecular Biology Reports·Yiyi SunLin Sun
Jun 18, 2011·Molecular Biology Reports·Na WangYan Li
Aug 21, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Yuan-Yuan WenChun-Xia Yang
May 24, 2014·PloS One·Qin QinXinchen Sun
May 14, 2016·Molecular Medicine Reports·Xinbao WangPengfei Yu
Feb 23, 2013·Medical Oncology·Ye LiYashuang Zhao
Nov 10, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yue HuLi Liu
Jun 17, 2011·Molecular Biology Reports·Sumei ZhangYuan Wang
Feb 1, 2011·Molecular Diagnosis & Therapy·Yumin LiQuanbao Zhang
Mar 4, 2010·BMC Medical Genetics·Xue Mei JinChan Choi
Jun 10, 2010·Molecular Biology Reports·Chun-xiao XuXian-xi Liu
Feb 2, 2013·Molecular Aspects of Medicine·Nicola J Curtin, Csaba Szabo