PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells.

Blood
Sung Hoon ChoMark Boothby

Abstract

Poly(ADP-ribos)ylation is one of the longest-known but most enigmatic posttranslational modifications transducing specific signals. The enzyme responsible for the majority of poly(ADP-ribose) polymerization in cells, PARP-1, promotes DNA repair but also mediates a caspase-independent form of apoptosis in response to stressors such as irradiation. However, the biologic function of most other PARPs is not known. Macro-PARPs constitute one branch of the large family of PARP-like proteins also designated as B aggressive lymphoma proteins (BAL1, 2a/2b, 3, or PARP-9, PARP-14, and PARP-15). To elucidate biologic role(s) of a BAL-family macro-PARP, we analyzed mice deficient in PARP-14, a binding partner of the IL-4-induced transcription factor Stat6. We show here that PARP-14 plays a fundamental role mediating protection against apoptosis in IL-4-treated B cells, including that after DNA damage, and mediates IL-4 effects on the levels of gene products that regulate cell survival, proliferation, and lymphomagenesis. Collectively, the results establish that PARP-14 mediates regulation of gene expression and lymphocyte physiology by IL-4 and has a function distinct from PARP-1. Furthermore, the findings suggest mechanisms by which BAL-fa...Continue Reading

References

Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·L H BoiseC B Thompson
Sep 12, 1997·Science·J E Darnell
Oct 6, 1997·Genes & Development·Z Q WangE F Wagner
Nov 11, 1998·Molecular Cell·J D LeversonS A Ness
Jun 8, 1999·Annual Review of Immunology·K NelmsW E Paul
Jun 22, 1999·The Journal of Clinical Investigation·G J VanasseD M Willerford
Mar 21, 2001·Cell·S J RiedlG S Salvesen
May 25, 2002·The Journal of Biological Chemistry·Andrea L WursterMichael J Grusby
May 3, 2003·The EMBO Journal·Josiane Ménissier de MurciaGilbert de Murcia
Jun 28, 2003·Experimental Hematology·Véronique J BouchardGuy G Poirier
Dec 12, 2003·Nature·Joseph T OpfermanStanley J Korsmeyer
Mar 27, 2004·Blood·Chrystelle GuiterFlavia Castellano
May 4, 2004·Trends in Pharmacological Sciences·Suk Jin HongValina L Dawson
Jul 10, 2004·Immunological Reviews·Sean RooneyFrederick W Alt
Sep 3, 2004·Human Pathology·Jeong Hee Cho-VegaL Jeffrey Medeiros
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara A StoutPaul J Bertics
Jan 12, 2005·The Journal of Experimental Medicine·Casey J FoxCraig B Thompson
Apr 20, 2005·Expert Reviews in Molecular Medicine·Nicola J Curtin
May 20, 2005·The EMBO Journal·Georgios I KarrasAndreas G Ladurner
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shreevrat Goenka, Mark Boothby
Jul 11, 2006·Nature Reviews. Molecular Cell Biology·Valérie SchreiberGilbert de Murcia
Sep 2, 2006·The EMBO Journal·José YélamosJosiane Ménissier-de Murcia
Sep 12, 2006·The Journal of Biological Chemistry·Claudia KeilShiao Li Oei
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Denise A Kaminski, Janet Stavnezer
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Seong-Woon YuValina L Dawson

❮ Previous
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Citations

Jun 6, 2013·Nature Reviews. Molecular Cell Biology·Karla L H FeijsBernhard Lüscher
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sung Hoon ChoMark Boothby
Nov 18, 2010·The Journal of Biological Chemistry·Purvi MehrotraShreevrat Goenka
Apr 5, 2012·The Journal of Experimental Medicine·Keunwook LeeMark Boothby
Jan 22, 2013·Cell Communication and Signaling : CCS·Karla Lh FeijsBernhard Lüscher
Jun 6, 2014·Nature Reviews. Cancer·Sejal Vyas, Paul Chang
Mar 5, 2013·Cellular and Molecular Life Sciences : CMLS·Melanija PosavecMarcus Buschbeck
Jul 28, 2010·Leukemia & Lymphoma·Wyndham H WilsonOwen A O'Connor
Sep 12, 2009·Expert Opinion on Therapeutic Patents·Gianluca PapeoAlessia Montagnoli
Mar 16, 2013·Immunology·Maria Manuela RosadoClaudio Pioli
Apr 18, 2013·The FEBS Journal·Emanuele S ScarpaMaria Di Girolamo
Sep 21, 2010·International Journal of Cancer. Journal International Du Cancer·Aswin Mangerich, Alexander Bürkle
Oct 2, 2015·Cells·Mareike BütepageBernhard Lüscher
Aug 31, 2016·Immune Network·Purna Krishnamurthy, Mark H Kaplan
Sep 30, 2016·Seminars in Cell & Developmental Biology·Melanija Posavec MarjanovićIvan Ahel
Oct 4, 2016·Seminars in Cell & Developmental Biology·Jeannette Abplanalp, Michael O Hottiger
Apr 19, 2016·The FEBS Journal·Florian J Bock, Paul Chang
Jan 17, 2017·Nature Chemical Biology·Nathan P WestcottHoward C Hang
Jan 21, 2017·European Journal of Immunology·Isabelle RobertBernardo Reina-San-Martin
Jun 28, 2017·Immunology·Purna KrishnamurthyMark H Kaplan
Nov 4, 2017·Critical Reviews in Biochemistry and Molecular Biology·Kerryanne CrawfordIvan Ahel
Feb 13, 2018·Apoptosis : an International Journal on Programmed Cell Death·Ingo GerhauserAndreas Beineke
Aug 4, 2010·Current Hematologic Malignancy Reports·Margaret T Kasner
Apr 18, 2019·Open Biology·Luca PalazzoIvan Ahel
May 6, 2019·Cellular and Molecular Life Sciences : CMLS·Yueshuang KeXueqing Ba
Jul 11, 2012·Korean journal of anesthesiology·Eunju LeeYoubin Son
Feb 8, 2020·Genes & Development·Anthony R FehrMasanori Aikawa
Jul 22, 2014·Nature Communications·Sejal VyasPaul Chang
Nov 14, 2018·Biochemical Society Transactions·Luca Palazzo, Ivan Ahel
Oct 5, 2017·Frontiers in Immunology·Gurupreet S SethiAmarjit S Naura
Mar 21, 2019·Frontiers in Pharmacology·Wei QinHui-Ling Cao
Dec 20, 2019·SLAS Discovery·Tim J WigleKevin W Kuntz
Dec 20, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ritobrata GoswamiMark H Kaplan
Nov 1, 2016·Nature Communications·Hiroshi IwataMasanori Aikawa
May 28, 2019·Frontiers in Endocrinology·Floriana D'AngeliVittoria Spina-Purrello
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sung Hoon ChoMark Boothby

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