PARP inhibitors for small cell lung cancer and their potential for integration into current treatment approaches.

Journal of Thoracic Disease
Ranya BarayanBenjamin H Lok

Abstract

Small cell lung cancer (SCLC) is a very aggressive, highly lethal, neuroendocrine tumor that constitutes 15% of all lung cancer cases. It is characterized by its rapid disease progression and high relapse rate leading to poor survival for diagnosed patients. Recently, poly (ADP-ribose) polymerase inhibitors (PARPi) have emerged as a novel therapeutic strategy for SCLC. Preclinical studies have demonstrated that PARPi possesses cytotoxic activity as a single-agent and in combination with other anti-cancer agents. Predictive biomarkers of response to PARPi, such as SLFN11, have also been described in SCLC. This review aims to summarize the recent preclinical investigations and the relevant clinical trials that evaluate PARPi in SCLC. Here, we highlight the potential role of PARPi in a biomarker-selected manner and in combination with chemotherapy, targeted agents, radiotherapy and immunotherapy.

Citations

May 6, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lauren Averett ByersPeter M Ellis
Jul 18, 2021·Lancet·Alesha A ThaiRebecca S Heist

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