Abstract
In the last three months, the whole scientific community has shifted its focus to the fight against the COVI-2 infection (COVID-19) trying to use different medications to save the patients' life. In some studies, the results were completely inconclusive, as in the case of chloroquine. However, the recent discovery on benefits deriving from use of such anticoagulants for Covid-19 patients, has increased the success of patients' treatment. Among lots of old and new drugs, PARP-inhibitors were not considered as possible option in the treatment of Covi-2 infection, being the latter able to induce the inflammatory and thrombotic cascades. Since PARP-inhibitors are able to reduce and block mechanisms leading to thrombosis and inflammation, they could be used as antithrombotic medications. Therefore, the present brief report is aimed to open the discussion on the potentials of PARP-inhibitors in non-oncological settings, like Covid-19.
References
Feb 2, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Marlene T Mathews, Bradford C Berk
Dec 19, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D LorussoG Ferrandina
Aug 16, 2016·European Journal of Human Genetics : EJHG·Ettore Capoluongo
Feb 19, 2017·British Journal of Pharmacology·Nathan A BergerCsaba Szabo
Jun 6, 2017·Targeted Oncology·Anna KukEwa Nowak-Markwitz
Aug 22, 2018·Annals of Surgical Oncology·Claudia MarchettiAnna Fagotti
Oct 10, 2018·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Ida ParisGiovanni Scambia
Mar 27, 2019·Future Oncology·Kelly E McCann
Oct 19, 2019·Targeted Oncology·Esha SachdevMonica M Mita
Mar 3, 2020·Journal of Autoimmunity·Hussin A Rothan, Siddappa N Byrareddy
Mar 14, 2020·The American Journal of Chinese Medicine·Kam Wa ChanSydney Chi Wai Tang
Mar 18, 2020·Lancet·Andrea Remuzzi, Giuseppe Remuzzi
Mar 29, 2020·Journal of Thrombosis and Haemostasis : JTH·Ning TangZiyong Sun
Apr 2, 2020·Viruses·Yuefei JinGuangcai Duan
Apr 16, 2020·International Journal of Molecular Sciences·Yung-Fang TuShih-Hwa Chiou
Apr 17, 2020·International Journal of Environmental Research and Public Health·Francesco Di GennaroLee Smith
Apr 28, 2020·Journal of Thrombosis and Haemostasis : JTH·Jecko ThachilToshiaki Iba
May 19, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hongyu XieGe Lou