PMID: 9432239Feb 12, 1998Paper

Pars plana implantation of a ganciclovir drug carrier in patients with cytomegalovirus retinitis and AIDS. Indications, follow-up and postoperative complications

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
H GümbelC Ohrloff

Abstract

We performed an open clinical trial to assess the safety and efficacy of a 1 microgram/h ganciclovir implant for the treatment of newly and pretreated cytomegalovirus (CMV) retinitis in patients with the acquired immunodeficiency syndrome (AIDS). Thirty-two eyes (20 patients) received the ganciclovir intraocular device and were prospectively followed up from 30 to 365 days. We used a modified technique for fixation of the device in half of the patients. The modification improved the fixation of the implant with a two-hole technique in the strut. Thirty eyes showed stabilization of the retinitis over the time, but in two patients resistance against ganciclovir and other nucleoside analogue compounds developed. Postoperative complications included vitreous hemorrhage (n = 1), cataract (n = 1), and uveitis anterior (n = 1). Late retinal detachment was seen in five eyes (25%) at 30 to 60 days after implantation. Followup until 1 year after implantation did not show progression of CMV retinitis in 18 to 20 patients. All received antiviral CMV therapy to protect noninfected eyes and intestinum against CMV infection. The ganciclovir intraocular device seemed to be effective in most cases of CMV retinitis and offers a promising alterna...Continue Reading

Citations

Dec 24, 1998·AIDS·D N RoseR Kleban
Aug 26, 1998·Australian and New Zealand Journal of Ophthalmology·P J McCluskeyP Versace

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