Parsing Myc Paralogs in Oncogenesis

Cancer Cell
Haritha Mathsyaraja, Robert N Eisenman

Abstract

Myc and its paralog MycN are thought to be functionally redundant, but Myc- and MycN-driven medulloblastomas exhibit distinct phenotypes. In this issue of Cancer Cell, Vo and colleagues (2016) show that this phenotypic difference stems from the preferential ability of Myc, relative to MycN, to bind Miz1 and repress transcription.

References

Feb 22, 2012·Cancer Cell·Daisuke KawauchiMartine F Roussel
Dec 4, 2013·Cold Spring Harbor Perspectives in Medicine·Katrin E WieseMartin Eilers
Jan 15, 2016·Cancer Cell·BaoHan T VoMartine F Roussel

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Citations

Apr 20, 2016·Nature Reviews. Clinical Oncology·Peter Sidaway
Mar 31, 2017·Genes·María Victoria Ruiz-PérezMarie Arsenian-Henriksson
Oct 19, 2019·Cell Death & Disease·Chantal Hoi Yin CheungHsueh-Fen Juan
Oct 1, 2020·Cell Stem Cell·Alfredo RodríguezAlan D D'Andrea
Mar 16, 2021·Frontiers in Oncology·Salvatore RaieliRoberto Tonelli

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