PMID: 15806447Apr 5, 2005

Part 1. Understanding the embryology and genetics of cleft lip and palate

Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses
Linda Merritt

Abstract

Craniofacial birth defects are the fourth most common congenital anomaly in newborns. Cleft lip and cleft palate (CL/CP) are the most common and immediately recognizable craniofacial anomalies. Some are diagnosed prenatally on ultrasound; more often, they are first noted in the delivery room. The infant may have a cleft that is unilateral, bilateral, complete, or incomplete, and it may involve the lip only, the palate only, or both. Cleft lip and/or cleft palate are often isolated nonsyndromic occurrences; however, when associated with other abnormal physical findings, a recognizable syndrome may be present. Part 1 of this 2-part article describes the incidence of CL/CP. The embryology of the face, lip, and palate are reviewed to enhance the understanding of the timing, complexity, and factors that may influence the development of this lesion. The emerging genetic links, environmental influences, and potential teratogens that may interact to contribute to CL/CP are discussed. Part 2 of this series will provide clinicians with tools to perform a focused risk assessment and obtain a detailed family and pregnancy history to evaluate for known associated risk factors for CL/CP. The article provides a guide for a systematic physical...Continue Reading

References

Jul 13, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Annette M Pham, Craig W Senders
Feb 10, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Haig A GoenjianMichael Moses
Aug 11, 2012·Magnetic Resonance Imaging Clinics of North America·David M MirskyLarissa T Bilaniuk
Aug 12, 2008·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Andrew F Pilon
Dec 17, 2014·Birth Defects Research. Part C, Embryo Today : Reviews·Mahdi A ShkoukaniPeter F Svider
Jul 6, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·A de BérailP Galinier
Jun 2, 2016·Spatial and Spatio-temporal Epidemiology·Jean Paul TannerRussell S Kirby
Jan 29, 2019·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Emeline MandalBjørn Øgaard
Nov 13, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Zachary R AbramsonAsim F Choudhri
Oct 14, 2017·World Journal of Methodology·Bram SmariusCorstiaan Breugem

Citations

Jan 1, 1981·American Journal of Medical Genetics·M MelnickH C Slavkin
Jul 1, 1993·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·C BallewR Lizarralde
Mar 1, 1993·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·J F Tulloch
Aug 10, 1999·American Journal of Medical Genetics·E E CastillaH Campaña
Sep 2, 2000·Journal of Pediatric Nursing·P L Bender
Mar 30, 2002·AORN Journal·Debra J SandbergMichael J Denk
May 29, 2002·Clinical Genetics·J C Murray
Jun 28, 2002·American Journal of Human Genetics·Mary L MarazitaYou-e Liu
Aug 2, 2002·Facial Plastic Surgery : FPS·Nina Wantia, Gerhard Rettinger
Mar 7, 2003·The Journal of Craniofacial Surgery·Francesco CarinciMauro Tognon
Jun 11, 2003·Neurology·Page B Pennell
Aug 5, 2003·Pediatrics·Abigail L ByrnesMary L Marazita
Jan 6, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lisa A DeRooLarry D Edmonds
Jan 14, 2004·Paediatric Anaesthesia·Charles Nargozian
Mar 3, 2004·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Linda D Vallino-NapoliJane Halliday
Mar 5, 2004·European Journal of Orthodontics·Martyn T Cobourne

Related Concepts

Congenital Neurologic Anomalies
Cleft Palate, Isolated
Thyroid Hormone Plasma Membrane Transport Defect
Harrod Doman Keele Syndrome
Midline Cell Component
Embryology
Cleft Palate With Cleft Lip
Cleft Lip
Ultrasonography
Entire Palate

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
T A GreggC F Coyle
© 2020 Meta ULC. All rights reserved