Parthenium hysterophorus: a probable source of anticancer, antioxidant and anti-HIV agents

BioMed Research International
Shashank KumarA K Pandey

Abstract

The present work reports the anticancer, antioxidant, lipo-protective, and anti-HIV activities of phytoconstituents present in P. hysterophorus leaf. Dried leaf samples were sequentially extracted with nonpolar and polar solvents. Ethanol fraction showed noticeable cytotoxic activity (81-85%) in SRB assay against MCF-7 and THP-1 cancer cell lines at 100  μg/ml concentration, while lower activity was observed with DU-145 cell line. The same extract exhibited 17-98% growth inhibition of HL-60 cancer cell lines in MTT assay, showing concentration dependent response. Ethanol extract caused 12% reduction in mitochondrial membrane potential and 10% increment in sub G1 population of HL-60 cell lines. Several leaf fractions, namely, ethyl acetate, ethanol, and aqueous fractions exhibited considerable reducing capability at higher concentrations. Most of the extracts demonstrated appreciable (>75%) metal ion chelating and hydroxyl radical scavenging activities at 200 µg/ml. All the extracts except aqueous fraction accounted for about 70-80% inhibition of lipid peroxidation in rat liver homogenate indicating protective response against membrane damage. About 40% inhibition of reverse transcriptase (RT) activity was observed in hexane fra...Continue Reading

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Citations

Jan 29, 2014·TheScientificWorldJournal·Shashank Kumar, Abhay K Pandey
Jan 24, 2014·TheScientificWorldJournal·Amita MishraAbhay K Pandey
Feb 28, 2015·Journal of Ethnopharmacology·Niharika SinghDinkar Sahal
Aug 25, 2015·Journal of Ethnopharmacology·Jazmín Espinosa-RiveroIrma Romero
Jul 6, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Chi-Yang LinJyh-Horng Wu
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ashutosh GuptaAbhay K Pandey
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kishor MazumderKoichi Fukase

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Methods Mentioned

BETA
Assay
ELISA
flow cytometry
fluorescence activated cell sorting
MDA

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