Parthenogenesis as a Solution to Hybrid Sterility: The Mechanistic Basis of Meiotic Distortions in Clonal and Sterile Hybrids.

Genetics
D. DedukhKarel Janko

Abstract

Hybrid sterility is a hallmark of speciation, but the underlying molecular mechanisms remain poorly understood. Here, we report that speciation may regularly proceed through a stage at which gene flow is completely interrupted, but hybrid sterility occurs only in male hybrids whereas female hybrids reproduce asexually. We analyzed gametogenic pathways in hybrids between the fish species Cobitis elongatoides and C. taenia, and revealed that male hybrids were sterile owing to extensive asynapsis and crossover reduction among heterospecific chromosomal pairs in their gametes, which was subsequently followed by apoptosis. We found that polyploidization allowed pairing between homologous chromosomes and therefore partially rescued the bivalent formation and crossover rates in triploid hybrid males. However, it was not sufficient to overcome sterility. In contrast, both diploid and triploid hybrid females exhibited premeiotic genome endoreplication, thereby ensuring proper bivalent formation between identical chromosomal copies. This endoreplication ultimately restored female fertility but it simultaneously resulted in the obligate production of clonal gametes, preventing any interspecific gene flow. In conclusion, we demonstrate tha...Continue Reading

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Citations

May 13, 2021·Biology Letters·Matthew Owen MoreiraDanny Rojas
Feb 17, 2021·Genome Biology and Evolution·Zuzana MajtánováTariq Ezaz
Jul 6, 2021·Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology·Seung Woon YunJong Young Park
Jul 27, 2021·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthias StöckKarel Janko
Aug 3, 2021·ELife·Vikas YadavJoseph Heitman

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Methods Mentioned

BETA
gene exchange
one hybrid
flow cytometry
electron microscopy
two hybrid

Software Mentioned

CorelTM DRAW graphics suite

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis