PMID: 4472Apr 1, 1976

Partial agonist properties and toxicity of oral oxilorphan

Journal of Clinical Pharmacology
E M Sellers, R Thakur

Abstract

Alternative pharmacologic adjuncts are needed for the management of opiate abuse. Oxilorphan, a narcotic antagonist, was studied at 5 different dose levels (1, 2, 4, 6, and 8 mg) in 30 normal subjects to determine the relation of single oral doses and toxicity. The drug causes pupillary constriction and mild central nervous system side effects (nausea, dizziness) at all doses. Mean urine volume increased (P less than 0.05) during the 12 hours after 1 and 2 mg. Oxilorphan has partial agonist properties similar to dl-cyclazocine.

References

Jan 1, 1972·Clinical Pharmacology and Therapeutics·D R Jasinski, P A Mansky
Jan 1, 1973·Annual Review of Medicine·D X Freedman, E C Senay
Jan 1, 1974·Archives of General Psychiatry·H KleberD Sweeney
Apr 1, 1974·Clinical Pharmacology and Therapeutics·J F Nutt, D R Jasinski
Mar 1, 1967·Clinical Pharmacology and Therapeutics·D R Jasinski, W R Martin

Citations

Jun 1, 1976·Drug and Alcohol Dependence·F S TennantE Ruckel

Related Concepts

Morphinans
Narcotic Antagonists
Pupil

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