Partial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptin

The Journal of Clinical Endocrinology and Metabolism
Talia Diker-CohenRebecca J Brown

Abstract

Lipodystrophies are extreme forms of metabolic syndrome. Metreleptin was approved in the United States for generalized lipodystrophy (GLD) but not partial lipodystrophy (PLD). The objective of the study was to test metreleptin's efficacy in PLD vs GLD and find predictors for treatment response. This was a prospective, single-arm, open-label study since 2000 with continuous enrollment. Current analysis included metreleptin treatment for 6 months or longer as of January 2014. The study was conducted at the National Institutes of Health (Bethesda, Maryland). Patients clinically diagnosed with lipodystrophy, leptin less than 8 ng/mL (males) or less than 12 (females), age older than 6 months, and one or more metabolic abnormalities (diabetes, insulin resistance, or hypertriglyceridemia) participated in the study. The interventions included sc metreleptin injections (0.06-0.24 mg/kg · d). Changes in glycated hemoglobin A1c (HbA1c) and triglycerides after 6 and 12 months of metreleptin were measured. Baseline metabolic parameters were similar in 55 GLD [HbA1c 8.4% ± 2.3%; triglycerides, geometric mean (25th, 75th percentile), 467 mg/dL (200, 847)] and 31 PLD patients [HbA1c 8.1% ± 2.2%, triglycerides 483 mg/dL (232, 856)] despite diff...Continue Reading

Citations

Jan 1, 2016·Cell Death & Disease·Y Poloz, V Stambolic
Mar 24, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Luis LeonDomingo Casadei
Mar 26, 2016·European Journal of Pharmacology·Kevin Y E StrehlerPhilip J Scarpace
Mar 31, 2016·Canadian Journal of Diabetes·Julien Vouillarmet, Martine Laville
Aug 5, 2015·Nature Reviews. Endocrinology·Nivedita Patni, Abhimanyu Garg
Nov 18, 2015·Clinical Endocrinology·Konstanze MiehleMathias Fasshauer
Sep 1, 2016·Journal of Clinical Lipidology·William Virgil BrownRobert Shamburek
Aug 9, 2016·Diabetes Research and Clinical Practice·Konstanze MiehleMathias Fasshauer
Sep 2, 2016·PloS One·Vikrant RachakondaJaideep Behari
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Rebecca J BrownPhillip Gorden
Dec 22, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Laura Papendieck, María B Araujo
May 4, 2018·The Journal of Clinical Investigation·Rebecca J BrownPhillip Gorden
Apr 29, 2018·Journal of Endocrinological Investigation·D Araújo-Vilar, F Santini
Dec 15, 2016·The Journal of Clinical Endocrinology and Metabolism·Nidhi GuptaM Hassan Murad
Apr 30, 2019·Annals of Internal Medicine·Alan Chait, Robert H Eckel
Jun 18, 2017·The EMBO Journal·Alexandros VegiopoulosStephan Herzig
Apr 17, 2019·The Journal of Clinical Endocrinology and Metabolism·Ho Lim LeeRebecca J Brown
May 29, 2019·Current Opinion in Lipidology·Audrey MelvinDavid B Savage
Apr 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Felix O OmoruyiLowell Dilworth
May 6, 2020·Expert Review of Endocrinology & Metabolism·Maria C Foss-FreitasElif A Oral
Jan 30, 2016·Endocrinology·Amy E LevensonSudha B Biddinger
Oct 3, 2020·International Journal of Molecular Sciences·Susan KralischKonstanze Miehle
Feb 6, 2020·Journal of the Endocrine Society·Shivraj GrewalRanganath Muniyappa
Dec 3, 2016·The Journal of Clinical Investigation·Jeffrey Friedman
Feb 16, 2017·Clinical Endocrinology·Nevin AjluniElif A Oral
Sep 12, 2020·Journal of the Endocrine Society·Silvia MagnoFerruccio Santini
Jul 17, 2018·The Journal of Clinical Investigation·Michael Rosenbaum, Rudolph L Leibel
Oct 4, 2017·The Journal of Clinical Endocrinology and Metabolism·Audrey MelvinDavid B Savage
Oct 30, 2018·Current Diabetes Reports·Baris AkinciElif Arioglu Oral
Dec 22, 2017·The Journal of Clinical Endocrinology and Metabolism·Iram HussainAbhimanyu Garg
Jul 18, 2019·The Journal of Clinical Endocrinology and Metabolism·Baris AkinciRebecca J Brown
Feb 16, 2021·The Journal of Clinical Investigation·Angeliki M AngelidiChristos S Mantzoros
Jan 15, 2021·Journal of the Endocrine Society·Marissa LightbourneRebecca J Brown
Jun 24, 2020·JCI Insight·Annah P BaykalRebecca J Brown
Mar 9, 2021·Journal of Neuromuscular Diseases·Antonio AtalaiaGisèle Bonne

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