Partial and massive lung lavages in an infant with severe pulmonary alveolar proteinosis

Pediatric Pulmonology
B MahutP Scheinmann


Pulmonary alveolar proteinosis is a rare disease of unknown etiology, characterized by progressive respiratory failure. Lung lavage has only been applied in a few children. A 6 month old boy suffering from severe pulmonary alveolar proteinosis was treated with three lung lavages. The first two were partial (or unilateral) lavages; a 3.5 mm flexible bronchoscope was introduced adjacent to a no. 3 cuffed endotracheal tube. This procedure allowed selective ventilation of one lung, and contralateral lung lavage. Respiratory improvement was observed during 1 week after the two procedures. At the third lavage we used partial veno-venous extracorporeal circulation because of severe respiratory failure. A significant improvement during the 5 following months was achieved. These results suggest that both partial and total lung lavage can be performed even in young infants and they may control the declining respiratory status in severe pulmonary alveolar proteinosis.


Nov 22, 1997·Pediatric Pulmonology·R V NachajonM H Collins
Aug 1, 1996·Pediatric Pulmonology·A Bush
Feb 26, 2004·Paediatric Respiratory Reviews·A LabbéM Albertini
Aug 19, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Rolf LindemannDrude Fugelseth
May 11, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Robert M DiBlasiMargaret Rosenfeld
Aug 19, 2011·BMC Pediatrics·Matthias GrieseAndreas Hector
Jun 15, 2014·Orphanet Journal of Rare Diseases·Laurent EnaudJacques de Blic
Dec 26, 2009·British Journal of Anaesthesia·O HodgesJ Thomas
Mar 31, 2009·Journal of Clinical Anesthesia·Deniz DoğruNural Kiper
Jan 5, 2011·Paediatric Anaesthesia·Karl ReiterThomas Nicolai
Nov 9, 2004·Paediatric Respiratory Reviews·Jacques de Blic
Mar 24, 2012·Revista brasileira de anestesiologia·Breno Monteiro GonçalvesPaulo Fernando Souto Bittencourt
Dec 16, 2017·The European Respiratory Journal·Ernst EberFabio Midulla


Aug 1, 1990·The American Review of Respiratory Disease·R A GoldsteinW J Metzger
Jan 1, 1989·Pediatric Pulmonology·R E SchumacherK P Heidelberger
Mar 1, 1989·Anesthesiology·B McKenzieA Bailey
Jun 1, 1987·Mayo Clinic Proceedings·U B PrakashH M Marsh
May 1, 1972·The Journal of Pediatrics·H ZellwegerW F McCormick
May 1, 1972·The Journal of Pediatrics·E M MazyckP N Symbas
Jun 1, 1971·American Journal of Diseases of Children·A R ColónE J O'Connell
Dec 1, 1966·Diseases of the Chest·J Ramirez
Feb 1, 1967·Archives of Disease in Childhood·J C HaworthH Taylor
May 1, 1983·Pediatric Research·G Lönnerholm, P J Wistrand
Mar 1, 1980·The American Review of Respiratory Disease·M ColemanT R Thompson
Nov 1, 1980·Chest·L J SmithB A Shapiro
Jun 5, 1958·The New England Journal of Medicine·S H ROSENA A LIEBOW

Related Concepts

Bronchoalveolar Lavage
Respiratory Failure
Lung Diseases
Rare Diseases
Ventilation, Function (Observable Entity)
Bronchial Lavage
Respiratory Insufficiency

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