Partial atrophy on prostate needle biopsy cores: a morphologic and immunohistochemical study

The American Journal of Surgical Pathology
Wenle WangJonathan I Epstein

Abstract

Partial atrophy is the most common benign mimicker of prostate cancer on needle biopsy. Of 3916 prostate needle core biopsy cases received in our consultation service over a period of 3 months (March 1, 2007 to May 31, 2007), 170 cases (4.3%) with partial atrophy were diagnosed as atypical glands by outside pathologists and prospectively identified. We supplemented our material with 108 cases of partial atrophy sent to our consultation service in 2006 from a single institution, which frequently uses a triple cocktail stain [p63, high molecular weight cytokeratin (HMWCK), alpha-methyl acyl-Coa racemase (AMACR)]. The morphologic features of the 278 cases and immunohistochemistry of 236 cases (198 with prostate cocktail and 38 with only basal cell makers) were analyzed. Forty-eight of 278 (17.3%) partial atrophy cases were mixed with postatrophic hyperplasia. Enlarged nuclei were visible in 43/278 (15.5%) cases, with prominent nucleoli seen in 58/278 (20.9%) cases (30 cases associated with nuclear enlargement). Of 198 cases with a prostatic cocktail stain, 48 (24.2%) had a cancer pattern for both basal cells and AMACR (p63-, HMWCK-, and AMACR+), 14 (7.1%) had a cancer pattern for basal cells (p63-, HMWCK-, and AMACR-), 89 (44.9%) ...Continue Reading

References

Apr 1, 1991·American Journal of Clinical Pathology·E E FrauenhofferA G Ayala
Dec 1, 1991·The American Journal of Surgical Pathology·E C JonesR H Young
Jan 1, 1987·The Journal of Urology·W A Gardner, D E Culberson
Apr 1, 1994·Human Pathology·T J SeboJ N Eble
Sep 1, 1995·The American Journal of Surgical Pathology·J C Cheville, D G Bostwick
Jul 1, 1995·The American Journal of Surgical Pathology·P B Gaudin, J I Epstein
May 1, 1997·The American Journal of Surgical Pathology·S J CinaJ I Epstein
Apr 16, 1998·The American Journal of Surgical Pathology·J R OppenheimerJ I Epstein
Oct 31, 2001·The American Journal of Surgical Pathology·Z JiangG R Fanger
Jan 25, 2002·Molecular Carcinogenesis·Jian-Hua LuoMichael Becich
Sep 10, 2002·The American Journal of Surgical Pathology·Zhong JiangXiming J Yang
Sep 27, 2006·The American Journal of Surgical Pathology·Angelo M De MarzoM S Lucia
Nov 1, 2006·American Journal of Clinical Pathology·Brian P Adley, Ximing J Yang

❮ Previous
Next ❯

Citations

Apr 19, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Geert J L H van LeendersJan Trapman
Mar 11, 2010·The American Journal of Surgical Pathology·Oksana YaskivPeter A Humphrey
Sep 2, 2010·PloS One·Regina Berretta, Pablo Moscato
Jan 24, 2014·Cancer Metastasis Reviews·Magdalena M GrabowskaRobert J Matusik
Jan 15, 2014·Cancer Metastasis Reviews·Rhonda L BittingAndrew J Armstrong
Nov 27, 2014·Archives of Pathology & Laboratory Medicine·Myra L WilkersonLiang Cheng
Apr 24, 2012·Annales de pathologie·Mathilde Sibony
Jan 4, 2012·Histopathology·Jonathan I Epstein
Jan 4, 2012·Histopathology·Glen Kristiansen
Oct 17, 2012·BJU International·Walter Artibani
Feb 6, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gro Linno Willemoe, Ben Vainer
Sep 8, 2010·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Athanase Billis
Aug 30, 2018·Advances in Anatomic Pathology·Roni M CoxJesse K McKenney
Apr 3, 2010·Virchows Archiv : an International Journal of Pathology·Athanase BillisLeandro L L Freitas
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kiril Trpkov
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peter A Humphrey
Aug 7, 2013·Virchows Archiv : an International Journal of Pathology·T Van der KwastUNKNOWN Pathology Committee of the European Randomized Study of Screening for Prostate Cancer (ERSPC)
May 27, 2011·Acta Oncologica·Anders BjartellLars Egevad
Apr 3, 2020·International Journal of Surgical Pathology·Julian Arista-NasrJorge Albores-Saavedra
Oct 20, 2020·Pathology·Lars EgevadHemamali Samaratunga
Mar 4, 2010·Archives of Pathology & Laboratory Medicine·Omar Hameed, Peter A Humphrey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.