PMID: 7025732May 1, 1981Paper

Partial characterisation of an oncofetal pancreatic antigen. Its role in the differential diagnosis and therapy of patients with pancreatic cancer

Annals of Clinical Biochemistry
M L Knapp

Abstract

An oncofetal pancreatic antigen (OPA) has been identified and purified from the blood of patients with pancreatic cancer. Characterisation studies on OPA have shown that it is a protein of molecular weight 40 000 with alpha2 electrophoretic mobility. OPA is clearly different from alpha-fetoprotein, carcinoembryonic antigen, ferritin, acute phase reactants, and normal serum proteins. A rocket immunoassay has been developed allowing the quantitation of OPA in serum; it has been applied to samples from over 700 individuals with a variety of conditions. Elevated levels of OPA have been found in 42 of 48 (88%) patients with biopsy-proven pancreatic cancer and in a much smaller percentage of patients with other cancers or with other conditions considered in the differential diagnosis of pancreatic cancer. The studies indicate that serum OPA measurements may be useful as a preliminary screening test for pancreatic cancer and for monitoring the course of the disease.

References

Jan 1, 1976·Annals of Clinical Biochemistry·A M Neville, E H Cooper
Jan 1, 1977·British Journal of Cancer·K M GrigorA M Neville
Jul 1, 1977·Gut·R G Morgan, K G Wormsley
Jun 1, 1978·Journal of the National Cancer Institute·A A Mihas
Mar 1, 1975·Cancer·M P Sullivan
Apr 1, 1974·Lancet·O BanwoJ R Hobbs
Jan 1, 1973·Journal of Surgical Oncology·S M Baylor, J W Berg
Oct 1, 1974·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·T SuzukiI Honjo

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Citations

Nov 1, 2001·Surgical Oncology Clinics of North America·P Burdiles, R L Rossi
Jan 1, 1998·Japanese Journal of Cancer Research : Gann·M TsutsumiY Konishi
Apr 26, 2006·Journal of Herbal Pharmacotherapy·Gauri Madhav Chauhan, Suresh R Naik
Dec 19, 2002·Surgical Oncology Clinics of North America·Jennifer F Tseng, Richard C Mulligan
Oct 1, 1994·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·T MoriY Konishi

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