PMID: 8589037Nov 1, 1995Paper

Partial chromosome 21 amplification in a child with acute lymphoblastic leukemia

Genes, Chromosomes & Cancer
M Le ConiatR Berger

Abstract

Monosomy 21 and metacentric markers corresponding in size to chromosomes 8 to 12 were found as the only clonal chromosomal changes in a child with acute lymphoblastic leukemia (ALL). chromosome painting with a whole chromosome 21-specific probe showed that the marker originated from chromosome 21. Fluorescence in situ hybridization with yeast artificial chromosome (YAC) probes to chromosome 21 showed genomic amplification with two, four, or more copies of the probed DNA sequences present on the marker. The most amplified regions of chromosome 21 were centromeric and telomeric to the Down's syndrome region. This observation supports the notion that amplification of only parts of chromosome 21 may be important in the leukemogenic process in spite of the high incidence of complete trisomy 21 in ALL.

References

Oct 1, 1992·Baillière's Clinical Haematology·N Sacchi
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H MiyoshiM Ohki
May 1, 1983·Cancer Genetics and Cytogenetics·H Van den BergheN Logghe
Oct 1, 1993·Genes, Chromosomes & Cancer·S P RomanaR Berger
Mar 1, 1994·Genes, Chromosomes & Cancer·S P RomanaR Berger
Dec 1, 1994·Genes, Chromosomes & Cancer·I PanagopoulosF Mitelman
Jan 1, 1993·European Journal of Human Genetics : EJHG·N CrétéN Créau-Goldberg
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·J R KorenbergC Disteche
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K ShimizuM Ohki

❮ Previous
Next ❯

Citations

Mar 10, 2001·Genes, Chromosomes & Cancer·P Dal CinC C Morton
Oct 2, 2001·Genes, Chromosomes & Cancer·M Busson-Le ConiatR Berger
May 4, 2001·Annales de génétique·M Busson-Le ConiatR Berger
Nov 7, 2000·Cancer Genetics and Cytogenetics·L RobinsonA Smith
Oct 24, 2001·Cancer Genetics and Cytogenetics·R BergerM T Daniel
Jan 22, 2002·Cancer Genetics and Cytogenetics·Marta SalidoLourdes Florensa
Jan 29, 2003·Cancer Genetics and Cytogenetics·Yolanda AlvarezM R Caballín
Mar 1, 1997·Cancer Genetics and Cytogenetics·R Berger
Nov 11, 1998·Cancer Genetics and Cytogenetics·M SankarN Kamada
Aug 9, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kaaren K ReichardSheldon Robinett
Feb 6, 2014·Leukemia·C J HarrisonO A Bernard
Oct 30, 2013·Leukemia·C J HarrisonUNKNOWN Ponte di Legno International Workshop in Childhood Acute Lymphoblastic Leukemia
Feb 3, 2016·European Journal of Medical Genetics·Christine J Harrison, Claire Schwab
Mar 14, 2007·Cancer Genetics and Cytogenetics·Roland Berger
Jan 24, 2007·Genes, Chromosomes & Cancer·Hazel M RobinsonJonathan C Strefford
Oct 12, 2004·Leukemia Research·Antoine Ribadeau DumasMichel Arock
Sep 22, 2000·Annales de génétique·S PaulienR Berger
Dec 8, 2004·Annales de génétique·Maryvonne BussonRoland Berger
Apr 18, 2002·Leukemia·M S Jabber Al-ObaidiUNKNOWN Medical Research Council Adult Leukaemia Working Party

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.