PMID: 9537555Apr 16, 1998Paper

Partial dearterialization of the spleen in thalassemia major

Journal of Pediatric Surgery
S A Banani

Abstract

Nine patients with thalassemia major (8 boys, 1 girl; age 3 to 8 years) who had signs of hypersplenism and required more than one blood transfusion per month (1 to 2 weeks) underwent partial dearterialization of the spleen (PDAS) from April through December 1992. All were on a low transfusion regimen (Hb < 10 g%). Hematologic profile, IgM and splenic dimensions (SD) by sonography were determined preoperatively and postoperatively during follow-up periods. Isotopic scan was also performed a few months and 2 to 4 years after operation. The patients did not receive pneumovax or long-term prophylactic antibiotics. The procedure consists of division of the splenic arterial branches, except the one that supplies the superior pole, along with preservation of all the veins. Seven patients with SD less than 11 cm (6.9 to 10.8 cm; four with less than 9.5 cm) had uneventful recovery. Two others with SD greater than 13 cm (13.2 to 13.5 cm) required total splenectomy a few days after PDAS because of splenic enlargement associated with high fever. One patient was lost to follow-up after 18 months. The remaining six patients underwent follow-up for 4 to 4.5 years. The hematologic profile (Hb, RBC, platelet counts) showed significant improveme...Continue Reading

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Citations

Nov 2, 2004·Surgical and Radiologic Anatomy : SRA·D IgnjatovicV Zivanovic
Feb 18, 2003·Acta chirurgica Iugoslavica·S KnezevićM Popović
Jan 13, 2006·Journal of Evolutionary Biology·W O H Hughes, J J Boomsma
Aug 17, 2006·Journal of Evolutionary Biology·A Gardner, S A West
Mar 1, 2014·Journal of Pediatric Hematology/oncology·Ahmed H Al-Salem
Feb 18, 2003·Acta chirurgica Iugoslavica·D IgnjatovićM Milićević

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