Partial decortication ameliorates dopamine depletion‑induced striatal neuron lesions in rats

International Journal of Molecular Medicine
Yaofeng ZhuWanlong Lei

Abstract

The balance between glutamate (cortex and thalamus) and dopamine (substantia nigra) inputs on striatal neurons is of vital importance. Dopamine deficiency, which breaks this balance and leads to the domination of cortical glutamatergic inputs, plays an important role in Parkinson's disease (PD). However, the exact impact on striatal neurons has not been fully clarified. Thus, the present study aimed to characterize the influence of corticostriatal glutamatergic inputs on striatal neurons after decortication due to dopamine depletion in rats. 6‑Hydroxydopamine was injected into the right medial forebrain bundle to induce dopamine depletion, and/or ibotenic acid into the primary motor cortex to induce decortication. Subsequently, the grip strength test and Morris water maze task indicated that decortication significantly shortened the hang time and the latency that had been increased in the rats subjected to dopamine depletion. Golgi staining and electron microscopy analysis showed that the total dendritic length and dendritic spine density of the striatal neurons were decreased in the dopamine‑depleted rats, whereas decortication alleviated this damage. Immunohistochemistry analysis demonstrated that decortication decreased the ...Continue Reading

References

Jul 1, 1990·Trends in Neurosciences·M R DeLong
Apr 15, 1985·The Journal of Comparative Neurology·G A GravelandM DiFiglia
Jan 1, 1983·Annual Review of Neuroscience·J B Penney, A B Young
Feb 1, 1995·Trends in Neurosciences·R L AlbinJ B Penney
Dec 1, 1995·Trends in Neurosciences·Y KawaguchiP C Emson
Nov 26, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·D A ShearG L Dunbar
Sep 15, 1999·Nature·J A Romashkova, S S Makarov
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 8, 2002·Annual Review of Neuroscience·Mark G Packard, Barbara J Knowlton
Jun 14, 2002·Experimental Neurology·Ronald DeumensJos Prickaerts
Jan 28, 2006·Nature Neuroscience·Charles R Gerfen
Apr 5, 2007·Nature Protocols·Charles V Vorhees, Michael T Williams
Nov 29, 2008·Neuron·Anatol C Kreitzer, Robert C Malenka
Feb 21, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rona K GrahamMichael R Hayden
Apr 30, 2009·Annual Review of Neuroscience·Anatol C Kreitzer
Apr 8, 2011·Annual Review of Neuroscience·Charles R Gerfen, D James Surmeier
Apr 13, 2013·Neuropharmacology·Stephan LammelRobert C Malenka
Feb 8, 2014·Journal of Neuroscience Methods·Luis Miguel Garcia-Segura, Julio Perez-Marquez
Sep 27, 2015·JAMA Neurology·Mahlon R DeLong, Thomas Wichmann
Jan 9, 2016·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Danqing Xiao
Feb 3, 2016·Neuron·Philip R L ParkerAnatol C Kreitzer
Aug 28, 2017·Current Opinion in Neurobiology·Shenyu ZhaiD James Surmeier
Dec 20, 2017·Proceedings of the National Academy of Sciences of the United States of America·Daniela RadlEmiliana Borrelli
May 4, 2018·Nature·Jones G ParkerMark J Schnitzer

❮ Previous
Next ❯

Citations

Sep 3, 2020·Neurotoxicity Research·Mona KhoramjouyMehrdad Faizi

❮ Previous
Next ❯

Methods Mentioned

BETA
electron
PCR
confocal microscopy

Software Mentioned

ImageJ
7500 system SDS
Neuron J
SPSS Statistics
TopScan

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Beiträge zur Klinik und Erforschung der Tuberkulose und der Lungenkrankheiten
W Lorbacher
Journal of the American Medical Association
H L SKINNER, K F FARR
The Journal of Thoracic Surgery
S E DOMMD H WATERMAN
Acta Chirurgica Scandinavica
P RUDSTROM, L THOREN
Beiträge zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung
E GAUBATZ
© 2021 Meta ULC. All rights reserved