Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken.

BMC Genomics
Martin G ElferinkMartien A M Groenen

Abstract

One of the loci responsible for feather development in chickens is K. The K allele is partially dominant to the k+ allele and causes a retard in the emergence of flight feathers at hatch. The K locus is sex linked and located on the Z chromosome. Therefore, the locus can be utilized to produce phenotypes that identify the sexes of chicks at hatch. Previous studies on the organization of the K allele concluded the integration of endogenous retrovirus 21 (ev21) into one of two large homologous segments located on the Z chromosome of late feathering chickens. In this study, a detailed molecular analysis of the K locus and a DNA test to distinguish between homozygous and heterozygous late feathering males are presented. The K locus was investigated with quantitative PCR by examining copy number variations in a total of fourteen markers surrounding the ev21 integration site. The results showed a duplication at the K allele and sequence analysis of the breakpoint junction indicated a tandem duplication of 176,324 basepairs. The tandem duplication of this region results in the partial duplication of two genes; the prolactin receptor and the gene encoding sperm flagellar protein 2. Sequence analysis revealed that the duplication is sim...Continue Reading

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Citations

Jul 3, 2013·Genome Biology and Evolution·Wen-Lang FanWen-Hsiung Li
Jun 8, 2010·BMC Genomics·Xiaofei WangNathaniel Adefope
Nov 19, 2010·BMC Genomics·Luca FontanesiBaldassare Portolano
Jun 15, 2013·BMC Genomics·Richard P M A CrooijmansMartien A M Groenen
Aug 14, 2013·Journal of Molecular Endocrinology·Guixian BuYajun Wang
Oct 19, 2010·Avian Pathology : Journal of the W.V.P.A·Pete Kaiser
Apr 14, 2012·Animal Genetics·A ClopM Amills
Mar 8, 2013·Genesis : the Journal of Genetics and Development·Almas A Gheyas, David W Burt
Feb 17, 2015·General and Comparative Endocrinology·Guixian BuYajun Wang
Nov 12, 2014·Annual Review of Animal Biosciences·Chih-Feng ChenCheng Ming Chuong
Feb 22, 2011·Cytogenetic and Genome Research·J B DodgsonH H Cheng
Jun 28, 2016·PloS One·Vinicius Henrique da SilvaLuiz Lehmann Coutinho
Mar 24, 2018·Genetics, Selection, Evolution : GSE·Martijn F L DerksMartien A M Groenen
May 29, 2018·Veterinary World·V BhanuprakashManjit Panigrahi
Apr 30, 2019·PLoS Genetics·Saber QanbariLeif Andersson
Jan 1, 2014·Microarrays·Xiaofei Wang, Shannon Byers
Jun 4, 2020·Genetics, Selection, Evolution : GSE·Andrew S MasonJacqueline Smith
Feb 3, 2012·Molecular Biology Reports·Chenglong LuoXiquan Zhang
May 10, 2017·International Journal of Molecular Sciences·Lingyang XuJiuzhou Song
Apr 29, 2020·Molecular Biology and Evolution·Chiara BortoluzziRichard P M A Crooijmans
Nov 9, 2016·Frontiers in Cellular and Infection Microbiology·Min FengXiquan Zhang
Oct 24, 2020·PloS One·Zhuoxian WengXunhe Huang
Dec 15, 2020·Animal Biotechnology·Xiaoting DingHua He
Feb 13, 2019·Trends in Plant Science·Zoe N Lye, Michael D Purugganan
May 19, 2021·BMC Genomics·Anna Carolina FernandesLuiz Lehmann Coutinho

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Methods Mentioned

BETA
PCR

Software Mentioned

Primer3
SDS1
Pregap4
Ensembl
Gap4
Staden

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