Partial expression of the viable motheaten (mev) mutation in the heterozygous state: abnormal levels of serum immunoglobulins and natural anti-ssDNA antibodies

Journal of Autoimmunity
L KuntzF Loor

Abstract

The 'viable motheaten' (mev) mutation in the C57BL/6 (B6) mouse causes a rapidly progressive and fatal autoimmune syndrome in mev-homozygous B6 mice, combined with generalized immunodeficiency, whereas the mev-heterozygous B6 mice look phenotypically normal. However, serological analyses of the levels of some spontaneously occurring, natural antibodies and of the levels and distribution of the different classes of immunoglobulins revealed mild but evident dysregulation of the natural humoral immunity of +/mev individuals.

References

Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C L SidmanL D Shultz

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Citations

Feb 1, 1992·Acta Physiologica Scandinavica·L Larsson
Feb 1, 1993·Acta Physiologica Scandinavica·L LarssonS Schiaffino
Jul 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Evelyn TsantikosMargaret L Hibbs

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