PMID: 8601607Apr 1, 1996Paper

Partial laminin alpha2 chain restoration in alpha2 chain-deficient dy/dy mouse by primary muscle cell culture transplantation

The Journal of Cell Biology
J T VilquinJ P Tremblay

Abstract

Laminin-2 is a component of skeletal and cardiac basal lamina expressed in normal mouse and human. Laminin alpha2 chain (LAMA2), however, is absent from muscles of some congenital muscular dystrophy patients and the dystrophia muscularis (dy/dy) mouse model. LAMA2 restoration was investigated following cell transplantation in vivo in dy/dy mouse. Allogeneic primary muscle cell cultures expressing the beta-galactosidase transgene under control of a muscular promoter, or histocompatible primary muscle cell cultures, were transplanted into dy/dy mouse muscles. FK506 immunosuppression was used in noncompatible models. All transplanted animals expressed LAMA2 in these immunologically-controlled models, and the degrees of LAMA2 restoration were shown to depend on the age of the animal at transplantation, on muscle pretreatment, and on duration time after transplantation in some cases. LAMA2 did not always colocalize with new or hybrid muscle fibers formed by the fusion of donor myoblasts. LAMA2 deposition around muscle fibers was often segmental and seemed to radiate from the center to the periphery of the injection site. Allogeneic conditionally immortalized pure myogenic cells expressing the beta-galactosidase transgene were charac...Continue Reading

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Citations

Oct 1, 1996·Current Opinion in Cell Biology·R Timpl
Sep 11, 2002·Neuromuscular Disorders : NMD·Terry Partridge
Mar 11, 2000·Neuromuscular Disorders : NMD·J T VilquinM Fiszman
Oct 22, 2003·Current Opinion in Rheumatology·Daniel Skuk, Jacques P Tremblay
Oct 18, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S Takeda, Y Miyagoe-Suzuki
Jan 6, 2011·Expert Opinion on Biological Therapy·Daniel Skuk, Jacques P Tremblay
Dec 2, 2004·Expert Opinion on Biological Therapy·Daniel Skuk
Aug 25, 2010·Muscle & Nerve·Jennifer MorganHala S Alameddine
Aug 15, 1998·Biochemical and Biophysical Research Communications·C HuardJ P Tremblay
Oct 11, 2005·Physical Medicine and Rehabilitation Clinics of North America·Baohong CaoJohnny Huard
Oct 1, 1998·Biochemical and Biophysical Research Communications·V BrusseeJ P Tremblay
Feb 19, 2000·Microscopy Research and Technique·D Hartigan-O'Connor, J S Chamberlain
Oct 31, 2000·Microscopy Research and Technique·K A McGowan, M P Marinkovich
Nov 3, 2016·Journal of Applied Physiology·Koyal Garg, Marni D Boppart
Sep 28, 2002·Current Opinion in Neurology·Daniel SkukJacques P Tremblay
Dec 11, 1999·Current Opinion in Neurology·C A Sewry, F Muntoni
Apr 1, 2004·Indian Journal of Pediatrics·Monisha Mukherjee, Balraj Mittal
Apr 1, 2000·Journal of Neuropathology and Experimental Neurology·D SkukJ P Tremblay
May 28, 2020·Frontiers in Molecular Neuroscience·Kinga I Gawlik, Madeleine Durbeej
Sep 19, 2020·The Journal of Clinical Investigation·Stefano BiressiThomas A Rando
Oct 8, 2004·Development·Naohiro HashimotoMasayo Inagawa-Ogashiwa

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