Partial liquid ventilation and positive end-expiratory pressure reduce ventilator-induced lung injury in an ovine model of acute respiratory failure

Critical Care Medicine
Craig A ReickertR B Hirschl

Abstract

To examine the isolated and combined effects of positive end-expiratory pressure (PEEP) and partial liquid ventilation (PLV) on the development of ventilator-induced lung injury in an ovine model. Prospective controlled animal study. University-based cardiovascular animal physiology laboratory. Thirty-eight anesthetized supine sheep weighing 22.3 +/- 2.2 kg. Animals were ventilated for 6 hrs (respiratory rate, 15; FIO2, 1.0, inspiratory/expiratory ratio, 1:1) with one of five pressure-controlled strategies, expressed as peak inspiratory pressure (PIP)/PEEP: low-PIP, 25/5 cm H2O (n = 8); high-PIP, 50/5 cm H2O (n = 8); high-PIP-PLV, 50/5 cm H2O-PLV (n = 8); high-PEEP, 50/20 cm H2O (n = 7); and high-PEEP-PLV, 50/20 cm H2O-PLV (n = 7). Compared with the low-PIP control, high-PIP ventilation increased airleak, shunt, histologic evidence of lung injury, neutrophil infiltrates, and wet lung weight. Maintaining PEEP at 20 cm H2O or adding PLV reduced the development of physiologic shunt and dependent histologic injury indexes. Neither higher PEEP nor PLV reduced the high incidence of barotrauma observed in high-PIP animals. We conclude that application of PLV or PEEP at 20 cm H2O may improve gas exchange and afford lung protection from...Continue Reading

References

Mar 11, 1975·Journal of Applied Physiology·I WyszogrodskiM E Avery
Oct 11, 1992·Pediatric Pulmonology·T H ShafferL C Clark
Jan 1, 1992·Intensive Care Medicine·B Lachmann
Aug 1, 1990·The American Review of Respiratory Disease·T C CorbridgeJ I Sznajder
Aug 1, 1990·Journal of Applied Physiology·D P CarltonR D Bland
Sep 1, 1987·The American Review of Respiratory Disease·L GattinoniM Bombino
Apr 1, 1987·Chest·R HaakeR R Henschen
Dec 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J C ParkerJ Thigpen
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
Jun 1, 1995·American Journal of Respiratory and Critical Care Medicine·L GattinoniF Valenza
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·J G MuscedereA S Slutsky
Jan 1, 1993·Intensive Care Medicine·A S Slutsky
Jul 1, 1996·Critical Care Medicine·D M SteinhornB A Holm
Mar 1, 1997·American Journal of Respiratory and Critical Care Medicine·M Colmenero-RuizG Vazquez-Mata

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Citations

Apr 20, 2004·Critical Care Medicine·Dana A SimonsonJohn J Marini
Nov 23, 2006·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Raymond RobertHervé Walti

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