Partial liquid ventilation: Effect of initial dose and redosing strategy in acute lung injury

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Mei-Jy JengT H Shaffer

Abstract

OBJECTIVE: Partial liquid ventilation (PLV) with perfluorochemicals has been shown to be effective in treating acute respiratory failure in animal studies and human trials. To determine the influences of perfluorochemicals on initial dose and redosing strategy, we studied their effects on gas exchange, pulmonary mechanics, and lung architecture. DESIGN: After lung injury was induced by repeated warm saline lavages, the animals were instilled endotracheally with different doses of perflubron during 5-10 mins in PLV-treated groups. The animals were randomized to five groups: PLV-12S (12 mL/kg perflubron, single dose), PLV-12M (12 mL/kg perflubron, multiple replacement doses), PLV-18S (18 mL/kg perflubron, single dose), PLV-18M (18 mL/kg perflubron, multiple replacement doses), and the control group (conventional mechanical ventilation only). Ventilator settings were kept constant during the 4-hr experiment. SETTING: An animal laboratory affiliated with Temple University School of Medicine. SUBJECTS: Twenty-eight New Zealand White juvenile rabbits (weight, 1.96 +/- 0.03 kg). INTERVENTIONS: Physiologic data were recorded every 30 mins. A constant volume (1.3 mL/kg/hr) of perflubron was replaced hourly in the PLV-12M and PLV-18M gro...Continue Reading

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Citations

May 25, 2005·Paediatric Respiratory Reviews·Marla R Wolfson, Thomas H Shaffer
Dec 16, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Mei-Jy JengThomas H Shaffer
May 4, 2011·Pediatric Pulmonology·Charalambos TsagogiorgasJuergen P Meinhardt

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