PMID: 9447875Feb 3, 1998Paper

Partial liquid ventilation with perfluorocarbon in the treatment of rats with lethal pneumococcal pneumonia

Anesthesiology
Eric W DicksonGary V Doern

Abstract

Partial liquid ventilation with perfluorocarbon is a new therapeutic strategy to treat various lung disorders. The current study was undertaken to determine the efficacy of partial liquid ventilation with a perfluorocarbon (FC-77) in the treatment of pneumococcal pneumonia in rats. Male Wistar rats (weight, 275-300 g; n, 75) were infected via direct intratracheal inoculation with ca 10(9) colony-forming units of viable Streptococcus pneumoniae, serotype 3, and 24 h after infection were placed into one of five groups, each containing 15 rats. The groups were (1) no treatment, (2) one intramuscular injection of penicillin G benzathine (200,000 U), (3) partial liquid ventilation with FC-77, (4) partial liquid ventilation with FC-77 and a single intramuscular dose of penicillin G benzathine (200,000 U), and (5) gas ventilation. Animals were observed every 24 h for survival. All untreated or gas-ventilated animals or animals that received only partial liquid ventilation were dead by 7 days. Those receiving only partial liquid ventilation survived longer than untreated controls, but ultimately all succumbed by day 7. Survival was 40% for penicillin-treated rats compared with controls (P < 0.05) and 80% for animals treated with both p...Continue Reading

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Citations

Dec 18, 2001·Pediatric Pulmonology·Mei-Jy JengBetau Hwang
Apr 20, 2001·Advanced Drug Delivery Reviews·M P Krafft
May 16, 2000·Critical Care Medicine·S O Heard, J C Puyana
Mar 13, 2002·Critical Care Medicine·Eric W DicksonGary V Doern
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A R FranzH D Hummler
Oct 3, 2006·Current Opinion in Anaesthesiology·R M Kacmarek
Jun 19, 2004·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K M SekinsT H Shaffer
Jan 12, 2000·Journal of Toxicology. Clinical Toxicology·M J BurnsW A Porcaro
May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dirk HaufeThea Koch
Sep 12, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey E GottsMichael A Matthay

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