Abstract
Partial liquid ventilation with perfluorocarbon is a new therapeutic strategy to treat various lung disorders. The current study was undertaken to determine the efficacy of partial liquid ventilation with a perfluorocarbon (FC-77) in the treatment of pneumococcal pneumonia in rats. Male Wistar rats (weight, 275-300 g; n, 75) were infected via direct intratracheal inoculation with ca 10(9) colony-forming units of viable Streptococcus pneumoniae, serotype 3, and 24 h after infection were placed into one of five groups, each containing 15 rats. The groups were (1) no treatment, (2) one intramuscular injection of penicillin G benzathine (200,000 U), (3) partial liquid ventilation with FC-77, (4) partial liquid ventilation with FC-77 and a single intramuscular dose of penicillin G benzathine (200,000 U), and (5) gas ventilation. Animals were observed every 24 h for survival. All untreated or gas-ventilated animals or animals that received only partial liquid ventilation were dead by 7 days. Those receiving only partial liquid ventilation survived longer than untreated controls, but ultimately all succumbed by day 7. Survival was 40% for penicillin-treated rats compared with controls (P < 0.05) and 80% for animals treated with both p...Continue Reading
References
Oct 11, 1992·Pediatric Pulmonology·T H ShafferL C Clark
Mar 1, 1992·Journal of Applied Physiology·M R WolfsonT H Shaffer
May 1, 1991·Critical Care Medicine·B P FuhrmanM DeFrancisis
Nov 1, 1995·Critical Care Medicine·D T WilcoxB P Fuhrman
Aug 1, 1995·Chest·R B HirschlR H Bartlett
Sep 1, 1995·Critical Care Medicine·T M SmithP Dandona
May 1, 1995·Critical Care Medicine·N H SalmanJ E Fischer
Sep 1, 1994·Critical Care Medicine·F D NestiB A Burak
Nov 1, 1993·Anesthesiology·A S TütüncüB Lachmann
Jul 1, 1993·Critical Care Medicine·A S TütüncüB Lachmann
Sep 1, 1993·The American Review of Respiratory Disease·A S TütüncüB Lachmann
Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·A GüntherW Seeger
Jan 1, 1996·Critical Care Medicine·M ContrerasJ J Zimmerman
Jul 1, 1996·Critical Care Medicine·D M SteinhornB A Holm
Jun 1, 1996·Critical Care Medicine·R B HirschlR H Bartlett
Nov 1, 1996·British Journal of Pharmacology·A van't VeenB Lachmann
Citations
Dec 18, 2001·Pediatric Pulmonology·Mei-Jy JengBetau Hwang
Apr 20, 2001·Advanced Drug Delivery Reviews·M P Krafft
May 16, 2000·Critical Care Medicine·S O Heard, J C Puyana
Sep 8, 2001·Critical Care Medicine·M RüdigerE Herting
Mar 13, 2002·Critical Care Medicine·Eric W DicksonGary V Doern
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A R FranzH D Hummler
Aug 22, 2003·Pediatric Research·Mario RudigerEgbert Herting
Jul 22, 2006·Pediatric Research·Heide WisselMario Rüdiger
Jan 29, 2000·Anesthesia and Analgesia·N D NaderD M Steinhorn
Oct 3, 2006·Current Opinion in Anaesthesiology·R M Kacmarek
Jan 3, 2001·Anesthesiology·T KochT Luther
Jun 19, 2004·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K M SekinsT H Shaffer
Jan 12, 2000·Journal of Toxicology. Clinical Toxicology·M J BurnsW A Porcaro
May 6, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dirk HaufeThea Koch
Sep 13, 2000·Physiological Measurement·M W Davies, K R Dunster
Sep 12, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jeffrey E GottsMichael A Matthay