Partial liver resection results in a significantly better long-term survival than locally ablative procedures even in elderly patients

Journal of Cancer Research and Clinical Oncology
A BauschkeU Settmacher

Abstract

The number of elderly patients with HCC will increase worldwide in the next years. Therefore, surgeons need to reassess clinical algorithms for the treatment of patients with HCC. We reevaluated a cohort of patients treated in the last 10 years at our hospital, with emphasis on long-term results and age. A prospectively recorded consecutive series of all patients treated in between January 1995 and December 2014 with curative intent either by partial liver resection or by ablative therapy was analysed. At the time of diagnosis, 232 patients were younger than 70 years and 127 patients were aged 70 years and over. In the latter group, solitary tumours, absence of liver cirrhosis and resection therapy were more frequent compared to younger patients. Charlson index, AFP-negative tumours and CLIP score were equally distributed in both groups. Observed survival of older and younger patients was similar but after partial liver resection, younger patients had a better survival than elderly patients, whereas survival in patients treated with ablation was similar in both groups. In the univariate analysis, long-term survival of patients aged 70 years and over was influenced by treatment procedure, number of lesions, liver cirrhosis, Chil...Continue Reading

References

Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Sep 14, 1999·The American Journal of Gastroenterology·R T PoonJ Wong
Oct 13, 1999·Seminars in Liver Disease·J M LlovetJ Bruix
Jun 30, 2000·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A ChiappaC Staudacher
Aug 10, 2005·World Journal of Surgery·Alessandro FerreroLorenzo Capussotti
Jul 22, 2008·World Journal of Surgery·Kazuhiro KondoJiro Ohuchida
Dec 4, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Koichi OishiToshimasa Asahara
Jan 6, 2009·Journal of Surgical Oncology·Masaki KaiboriA-Hon Kwon
Oct 5, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hirokazu TakahashiKazuma Fujimoto
May 5, 2011·Digestive Surgery·Giulio BelliPaolo Limongelli
Nov 1, 2011·Japanese Journal of Clinical Oncology·Nazario PortolaniStefano Maria Giulini
Mar 20, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver, UNKNOWN European Organisation For Research And Treatment Of Cancer
Jul 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Cho Rok LeeKyung Sik Kim
Oct 25, 2013·Journal of Cancer·Hiroki NishikawaYukio Osaki
Nov 28, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W FaberD Seehofer
Jan 1, 2014·World Journal of Gastroenterology : WJG·Kazuto Tajiri, Yukihiro Shimizu
Jan 15, 2014·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Nobuhiko TaniaiEiji Uchida
Oct 7, 2014·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Wing Chiu DaiRonnie T P Poon
Nov 12, 2014·World Journal of Gastroenterology : WJG·Koichi OishiMikiya Kitamoto

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Citations

Dec 14, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Roberto SantambrogioEnrico Opocher
Aug 1, 2018·World Journal of Surgery·Brian K P GohAlexander Y F Chung
Aug 28, 2018·Expert Review of Gastroenterology & Hepatology·Ling-Yun ZhaoJian-Hong Zhong
Aug 2, 2019·World Journal of Gastroenterology : WJG·Kevin Ka Wan Chu, Kenneth Siu Ho Chok
Jul 1, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Iestyn M ShapeyNicola de Liguori Carino

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