Partial nephrectomy seems to confer a survival benefit relative to radical nephrectomy in metastatic renal cell carcinoma

Cancer Epidemiology
Elio MazzonePierre I Karakiewicz

Abstract

Partial nephrectomy (PN) is technically feasible in patients with metastatic renal cell carcinoma (mRCC). We tested the contemporary effect of PN on cancer-specific mortality (CSM), other-cause mortality (OCM) and early postoperative outcomes compared to radical nephrectomy (RN) in mRCC patients. In the first part, we identified surgically treated mRCC patients within the SEER database (2004-2013). After propensity-score (PS) matching, cumulative incidence plots and multivariable competing-risks regression (CRR) models were used. In the second part, we identified surgically treated mRCC patients within the NIS database (2004-2013). After PS matching, multivariable logistic regression (MLR) and multivariable Poisson regression (MPR) models were used. Within the SEER database, 217 (4.2%) of 5171 mRCC patients underwent PN. After 4:1 PS matching, multivariable CRR models showed lower OCM rates in PN patients (hazard ratio [HR]: 0.23, p = 0.01). No difference in CSM was reported in PN vs. RN patients (p = 0.08). Within the NIS database, 226 (4.4%) of 5138 patients underwent PN. After 4:1 PS matching, MLR showed lower rates of transfusions (odds ratio [OR]: 0.46, P < 0.001), intraoperative (OR: 0.33, p = 0.02) and miscellaneous surg...Continue Reading

Citations

Jan 19, 2021·Journal of Endourology Case Reports·Nima MikailRabii Madi
Jul 6, 2020·Current Drug Targets·Francesco GrecoRoberto M Scarpa
Jun 20, 2020·European Urology Oncology·Maria Carmen MirUNKNOWN EAU Section of Oncological Urology (ESOU) Board

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