Partial or near-total pancreatectomy for nesidioblastosis?

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie
K ParasharJ J Corkery

Abstract

We report on 11 consecutive cases of nesidioblastosis successfully managed, in a 22-year period from 1972-1993 at The Children's Hospital, Birmingham, England. In the pre-operative period all patients were managed by constant glucose administration ( > 10 mg/kg/min) and hyperglycaemic agents such as diazoxide, glucagon, growth hormone and somatostatin either singly or in combination. Seven patients underwent partial pancreatectomy, 2 of whom needed a subsequent near-total resection; 4 others had a near-total pancreatectomy as the primary procedure. The 5 patients who have had partial pancreatectomies are healthy and on no regular medication. Of the 6 patients who had near-total pancreatectomy 3 require insulin for diabetes mellitus and 3 are on pancreatin for pancreatic exocrine deficiency. We recommend partial pancreatectomy as the first operation in the treatment of nesidioblastosis.

Citations

Dec 28, 2010·Seminars in Pediatric Surgery·Anja LudwigKlaus Mohnike
Sep 18, 1998·Journal of Pediatric Gastroenterology and Nutrition·A CadeJ W Puntis
Feb 26, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·P MahachoklertwattanaC Preeyasombat
Jun 27, 1998·Journal of Pediatric Endocrinology & Metabolism : JPEM·C Dacou-VoutetakisM Maniati-Christidis

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