Partial peripheral motor nerve lesions induce changes in the conduction properties of remaining intact motoneurons

Muscle & Nerve
L A HavtonJ O Kellerth

Abstract

A partial injury or loss of peripheral motor axons is followed by compensatory sprouting of remaining intact motor axons in order to reinnervate muscle. Little is known, however, about the electrophysiologic properties proximally of these intact motoneurons and their axons following injury of neighboring motor axons. We studied the conduction properties of intact cat motor axons and motoneurons proximal to the site of a partial peripheral nerve section. Twelve weeks after the partial transection of the cat medial gastrocnemius motor nerve, there was a significant (7%) reduction in conduction velocity and a 13% prolongation in afterhyperpolarization half-decay time in the remaining intact motoneurons, compared with controls. Partial injury to motor nerves thus induces reactive electrophysiologic changes in the remaining intact motoneurons and their axons, perhaps associated with compensatory sprouting within partially denervated muscle.

References

Feb 1, 1976·The Journal of Physiology·L M MendellJ G Scott
Feb 1, 1977·The Journal of Physiology·P HuizarY Miyata
May 1, 1988·Journal of Neurophysiology·A R LuffK Torkko
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P N HoffmanD L Price
Aug 1, 1974·The Journal of Physiology·M KunoE J Muñoz-Martinez
Aug 1, 1984·The Journal of Cell Biology·P N HoffmanD L Price
Jan 1, 1981·Annual Review of Neuroscience·M C BrownW G Hopkins
Jun 1, 1996·The Journal of Cell Biology·Z XuD W Cleveland
Sep 1, 1953·The Quarterly Review of Biology·M V EDDS
Aug 29, 1958·The Journal of Physiology·J C ECCLESR R YOUNG
Nov 1, 1967·The Journal of Physiology·R E Burke

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Citations

Jun 19, 2010·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ferdinando SartucciAlessandro Rossi
Jun 29, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ming-Hong ChangSan-Yong Huang
Jun 14, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ming Hong ChangLee Wei Chen
Jan 22, 2009·Human Molecular Genetics·Elena KudryashovaMelissa J Spencer
May 13, 2008·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Ming-Hong ChangPeiyuan F Hsieh
Sep 28, 2002·Current Opinion in Neurology·Christian Krarup
Nov 4, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ming-Hong ChangPeiyuan F Hsieh
Sep 29, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hatice TankisiAnders Fuglsang-Frederiksen
Feb 20, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Leif A HavtonJan-Olof Kellerth
Jul 19, 2005·Muscle & Nerve·Christine K Thomas, Inge Zijdewind
Feb 16, 2011·Muscle & Nerve·Sudath M GunasekeraHewa G R Sesath
Aug 2, 2013·Acta Physiologica·C K ThomasI Zijdewind
Nov 18, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ming-Hong ChangPeiyuan F Hsieh
Apr 24, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Niels O B ThomsenLars B Dahlin
Apr 14, 2006·Journal of Neurophysiology·C K Häger-RossC K Thomas
Oct 23, 2002·Journal of Applied Physiology·Jane E Butler, Christine K Thomas
Jan 12, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jongsuk ChoiKyung Seok Park
Mar 19, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·C S KleinM A Fisher

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