Partial protection against four species of chicken coccidia induced by multivalent subunit vaccine

Veterinary Parasitology
Xiaokai SongXiangrui Li

Abstract

In this study, a multivalent subunit vaccine was designed to protect chickens against simultaneous infection by several Eimeria species. This vaccine contains recombinant proteins from four Eimeria species - E. tenella, E. necatrix, E. acervulina and E. maxima - and was evaluated for efficacy in animals. To produce this vaccine, candidate antigens from each Eimeria species were first screened in chickens via intramuscular inoculation and subsequent challenge. Antigens tested include recombinant proteins TA4 and SO7 from E. tenella, NA4 and NPmz19 from E. necatrix, LDH, 3-1E and MIF from E. acervulina, and Em6 and Em8 (two portions of EmTFP250) from E. maxima. A homologous challenge was then performed to identify which antigen from each species conferred the best protection. The antigens identified as most protective against its species were then challenged by heterologous species. Finally, the selected recombinant proteins from each of the four respective species were mixed with the final concentration of 400 μg/ml (100 μg of each protein/ml) to form the multivalent subunit vaccine, which was tested for efficacy in animals. The results indicated that TA4 from E. tenella, NA4 from E. necatrix, LDH from E. acervulina, and Em8 fro...Continue Reading

References

Sep 22, 2001·Biomolecular Engineering·D T O'HaganM Singh
Sep 5, 2002·Veterinary Immunology and Immunopathology·G L OshopR A Heckert
Oct 25, 2002·Avian Pathology : Journal of the W.V.P.A·R B Williams
Jun 20, 2003·International Journal for Parasitology·David M WitcombeNicholas C Smith
May 10, 2005·Experimental Parasitology·Alireza Talebi, Grace Mulcahy
Feb 3, 2006·Expert Review of Vaccines·Rami A Dalloul, Hyun S Lillehoj
Jul 16, 2010·Parasite Immunology·P A SharmanM Katrib
Dec 25, 2012·Research in Veterinary Science·Hongyan SongXiangrui Li
Nov 19, 2013·Trends in Parasitology·Damer P Blake, Fiona M Tomley
Feb 19, 2014·Parasitology·David M Witcombe, Nicholas C Smith
Jul 13, 2014·Genome Research·Adam J ReidArnab Pain

❮ Previous
Next ❯

Citations

Dec 25, 2012·Research in Veterinary Science·Hongyan SongXiangrui Li
Dec 13, 2018·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Abiodun Joseph Fatoba, Matthew Adekunle Adeleke
Jun 3, 2021·Parasite : Journal De La Société Française De Parasitologie·Thabile MadlalaMatthew Adekunle Adeleke
Jun 9, 2021·Journal of Applied Microbiology·Mohammad Fatemi Motlagh, S Latif Mousavi Gargari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.