PMID: 6068Jan 1, 1976

Partial purification and study of gamma-glutamyl transpeptidase from sheep cerebral capillaries

Biochimie
M Grandgeorge, P Morelis

Abstract

Gamma-glutamyl transpeptidase was purified 53 times from Sheep brain cortex capillaries. On gel filtration it appears homogeneous with a M.W. = 350 000. The enzyme is likely a glycoprotein, the properties of which are close to hog kidney gamma-glutamyl transpeptidase ; gamma-glutamyl aminoacid formation is assayed electrophoretically. The results obtained using several aminoacids are in favour of the existence of different units, specific of each group of aminoacids ; together with the data from structural analogs, they support the hypothesis that gamma-glutamyl transpeptidase participates in aminoacid transport accross blood brain barrier.

Citations

Jul 1, 1984·Neurochemical Research·J Veselý, M Cernoch
Mar 1, 1983·Veterinary Research Communications·J P BraunA G Rico
Oct 1, 1985·Neurochemical Research·J VeselýM Cernoch
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Pajari

Related Concepts

Metazoa
Blood - Brain Barrier Anatomy
Blood Capillaries
Insula of Reil
Gamma-glutamyl transferase
Dall Sheep
PMS-Tryptophan

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