PMID: 54919Feb 1, 1976Paper

Partial purification of a serum factor that causes necrosis of tumors

Proceedings of the National Academy of Sciences of the United States of America
S GreenM K Schwartz

Abstract

Tumor necrosis can be induced in transplanted mouse methylcholanthrene-induced sarcoma by a tumor necrosis factor in the serum of mice infected with bacillus Calmette-Guérin and given bacterial endotoxin. Sera from normal mice, endotoxin-treated mice, and mice infected with bacillus Calmette-Guérin do not contain this factor. A 20- to 30-fold purification of the serum factor has been achieved by (NH4)2SO4 fractionation, Sephadex G-100 and G-200 gel filtration, and preparative polyacrylamide electrophoresis. Tumor necrosis factor is not bacterial endotoxin. It migrates with alpha-globulins, is made up of at least four subunits, and has a molecular weight of about 150,000. The active factor is a glycoprotein that contains sialic acid and galactosamine.

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB D Williamson
Jul 1, 1969·Analytical Biochemistry·R M ZachariusJ J Woodlock
May 1, 1970·European Journal of Biochemistry·W DrögeO Westphal
Jul 21, 1971·Nature: New Biology·P Alexander, R Evans

Citations

Apr 15, 1987·Klinische Wochenschrift·R Munker, H P Koeffler
Aug 31, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y AbeS Kimura
Jan 1, 1993·Pharmacology & Therapeutics·R S Sidhu, A P Bollon
Aug 1, 1991·Veterinary Immunology and Immunopathology·R J MacKayL A Skelley
Aug 1, 1996·The International Journal of Biochemistry & Cell Biology·D R Branch, L J Guilbert
Dec 30, 1988·Biochemical and Biophysical Research Communications·K H Lee, K H Kim
Jan 1, 1985·Experimental Pathology·D Zippel
Mar 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M K HoffmannU Hammerling
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B D WilliamsonL J Old
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F C Kull, P Cuatrecasas
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·D PennicaD V Goeddel
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B Y RubinL J Old
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K HaranakaL J Old
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D S Silberstein, J R David
Dec 1, 1977·The Journal of Experimental Medicine·M K HoffmannH F Oettgen
Dec 1, 1978·The Journal of Experimental Medicine·M J BerendtD P Kirstein
Jun 25, 1985·Nucleic Acids Research·L FransenA Van Vliet
May 1, 1994·American Journal of Reproductive Immunology : AJRI·M J Rewinski, T J Yang
Sep 26, 2013·BioMed Research International·Subhadip ChakrabortyKunal Ray
Dec 17, 2009·Expert Opinion on Pharmacotherapy·James PadsisDouglas Tyler
Feb 5, 2015·Current Medical Research and Opinion·Hervé LebrecMichele Hooper
Jan 9, 2016·Regulatory Toxicology and Pharmacology : RTP·H LebrecR D Mellon
Feb 7, 2012·Biochemical Pharmacology·Anton KuratnikCharles Giardina
Oct 20, 1999·Cytokine·D T Humphreys, M R Wilson
Mar 6, 2013·The Journal of Pathology·John P WatersJohn R Bradley
May 7, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E Jensen-Jarolim, J Singer
Jun 1, 1984·Immunology Today·J H PlayfairN Matthews
Jan 1, 1988·Annals of the New York Academy of Sciences·J C Hiserodt, W H Chambers
Dec 31, 1990·Biochemical and Biophysical Research Communications·B SherryA Cerami
Nov 10, 2009·The Journal of Allergy and Clinical Immunology·Lisa C ZabaJames G Krueger
Jun 1, 1983·Immunology Today·D O Adams, C F Nathan
Jan 1, 1990·Critical Reviews in Clinical Laboratory Sciences·J S Warren
May 1, 2009·Expert Review of Endocrinology & Metabolism·Jean Calleja-AgiusEric Jauniaux
Nov 1, 1977·CRC Critical Reviews in Toxicology·L J Berry
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Charlotte Eielson Ariyan, Mary Sue Brady
May 12, 2020·Frontiers in Oncology·María Florencia MercoglianoRoxana Schillaci
Nov 1, 1977·Cancer·G LipkinM Rosenberg
Sep 1, 1990·Journal of the American Geriatrics Society·B Beutler
Jan 1, 1986·Acta Medica Scandinavica·C P Maury
Mar 15, 1985·European Journal of Biochemistry·R ThorstenssonR Norberg
Nov 1, 1992·European Journal of Haematology·B SchleiffenbaumJ Fehr
Oct 15, 1988·International Journal of Cancer. Journal International Du Cancer·E ProiettiF Podo
Jan 1, 1979·Journal of Immunopharmacology·S M Mikulski, M A Chirigos
Aug 15, 1987·International Journal of Cancer. Journal International Du Cancer·T NishimuraY Hashimoto
Jan 1, 1989·Seminars in Surgical Oncology·H J Wanebo
Feb 6, 2021·Cancers·María Florencia MercoglianoRoxana Schillaci

Related Concepts

Alpha-Globulins
BCG Vaccine
Serum Proteins
Endotoxins
Fibrosarcoma
Galactosamine
Neoglycoproteins
Methylcholanthrene
Mycobacterium bovis
Necrosis

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
E A CarswellB D Williamson
International Archives of Allergy and Applied Immunology
C I Smith, L Hammarström
International Archives of Allergy and Applied Immunology
D TripodiW Pollack
© 2021 Meta ULC. All rights reserved